Insights into recent findings and therapeutic potential of nonhistone lactylation in cancer.

IF 3.9 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Frontiers in Molecular Biosciences Pub Date : 2025-09-09 eCollection Date: 2025-01-01 DOI:10.3389/fmolb.2025.1661697

Jing Jia, Na Liu, Xiaoren Zhu, Minbin Chen

引用次数: 0

Abstract

Lactylation, a recently identified post-translational modification, has become a crucial regulatory mechanism beyond its conventional metabolic role. Unlike histone lactylation, which regulates gene expression, nonhistone lactylation directly acts on effector proteins involved in processes such as signal transduction, metabolic reprogramming, and DNA damage repair. This article systematically reviews how nonhistone lactylation regulates biological processes related to cancer via mechanisms such as modulating protein interactions, stability, subcellular localization, and enzymatic activity. In addition, it comprehensively examines the potential applications and challenges in targeting nonhistone lactylation modification in antitumor treatment.

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非组蛋白乳酸化在癌症中的最新发现和治疗潜力。

乳酸化，最近发现的翻译后修饰，已经成为一个重要的调节机制超越其传统的代谢作用。与调节基因表达的组蛋白乳酸化不同，非组蛋白乳酸化直接作用于参与信号转导、代谢重编程和DNA损伤修复等过程的效应蛋白。本文系统地回顾了非组蛋白乳酸化如何通过调节蛋白质相互作用、稳定性、亚细胞定位和酶活性等机制调节与癌症相关的生物过程。此外，本文还全面探讨了靶向非组蛋白乳酸化修饰在抗肿瘤治疗中的潜在应用和挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Molecular Biosciences Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

7.20

自引率

4.00%

发文量

1361

审稿时长

14 weeks

期刊介绍： Much of contemporary investigation in the life sciences is devoted to the molecular-scale understanding of the relationships between genes and the environment — in particular, dynamic alterations in the levels, modifications, and interactions of cellular effectors, including proteins. Frontiers in Molecular Biosciences offers an international publication platform for basic as well as applied research; we encourage contributions spanning both established and emerging areas of biology. To this end, the journal draws from empirical disciplines such as structural biology, enzymology, biochemistry, and biophysics, capitalizing as well on the technological advancements that have enabled metabolomics and proteomics measurements in massively parallel throughput, and the development of robust and innovative computational biology strategies. We also recognize influences from medicine and technology, welcoming studies in molecular genetics, molecular diagnostics and therapeutics, and nanotechnology. Our ultimate objective is the comprehensive illustration of the molecular mechanisms regulating proteins, nucleic acids, carbohydrates, lipids, and small metabolites in organisms across all branches of life. In addition to interesting new findings, techniques, and applications, Frontiers in Molecular Biosciences will consider new testable hypotheses to inspire different perspectives and stimulate scientific dialogue. The integration of in silico, in vitro, and in vivo approaches will benefit endeavors across all domains of the life sciences.