Profilin and Its Isoforms: Unravelling the Functional Diversity Across Life Forms.

IF 2 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current protein & peptide science Pub Date : 2025-09-22 DOI:10.2174/0113892037390621250901052506

Nupur Pathak, V Kohila

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引用次数: 0

Abstract

The dynamic nature of the cell wall or plasma membrane is extremely important for the various cellular functions. The rearrangement of the cytoskeleton within the cell is a crucial process that is coordinated by the Profilin (PFN) protein. PFN is a small, cytosolic protein whose molecular weight is around 14-17 kDa. Originally, PFN was identified as an actin-binding protein that regulates actin dynamics. However, several studies later reported that the interaction of PFN with certain cytosolic proteins has a role in membrane trafficking, development, motility, and signaling. Additionally, the alternatively spliced PFN isoforms are present in different tissues and govern neurological and developmental functions. A mutation in these isoforms can result in abnormalities in the functioning. These isoforms interact with different ligands with certain specificity. However, the structural and functional biology of these isoforms is still under investigation. This review comprehensively discusses the roles of PFN and its isoforms across diverse species, spanning prokaryotes, eukaryotes, and viruses. Future research efforts are crucial for elucidating novel aspects and enhancing our understanding of the molecular mechanisms governed by PFN and its isoforms.

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剖面蛋白及其异构体：揭示生命形式的功能多样性。

细胞壁或质膜的动态性质对细胞的各种功能至关重要。细胞骨架在细胞内的重排是由Profilin （PFN）蛋白协调的关键过程。PFN是一种小的细胞质蛋白，分子量约为14- 17kda。最初，PFN被确定为一种调节肌动蛋白动力学的肌动蛋白结合蛋白。然而，后来的一些研究报道了PFN与某些细胞质蛋白的相互作用在膜运输、发育、运动和信号传导中起作用。此外，可选择剪接的PFN亚型存在于不同的组织中，并控制神经和发育功能。这些异构体的突变会导致功能异常。这些同工异构体以一定的特异性与不同的配体相互作用。然而，这些同工异构体的结构和功能生物学仍在研究中。本文综述了PFN及其亚型在原核生物、真核生物和病毒等不同物种中的作用。未来的研究工作对于阐明新的方面和加强我们对PFN及其同工异构体控制的分子机制的理解至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current protein & peptide science 生物-生化与分子生物学

CiteScore

5.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Current Protein & Peptide Science publishes full-length/mini review articles on specific aspects involving proteins, peptides, and interactions between the enzymes, the binding interactions of hormones and their receptors; the properties of transcription factors and other molecules that regulate gene expression; the reactions leading to the immune response; the process of signal transduction; the structure and function of proteins involved in the cytoskeleton and molecular motors; the properties of membrane channels and transporters; and the generation and storage of metabolic energy. In addition, reviews of experimental studies of protein folding and design are given special emphasis. Manuscripts submitted to Current Protein and Peptide Science should cover a field by discussing research from the leading laboratories in a field and should pose questions for future studies. Original papers, research articles and letter articles/short communications are not considered for publication in Current Protein & Peptide Science.