Obesity and Metabolic Syndrome: Current Insights and Future Directions.

IF 1.8 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL
British journal of hospital medicine Pub Date : 2025-09-25 Epub Date: 2025-09-05 DOI:10.12968/hmed.2025.0127
Zaiem Zarkasi, Rajshekhar N Mudaliar, Waseem A Majeed, Akheel A Syed
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引用次数: 0

Abstract

Obesity and metabolic syndrome are global health challenges, significantly increasing risks for type 2 diabetes, cardiovascular and cerebrovascular diseases, and overall mortality. This narrative review aims to discuss the relationship between obesity and metabolic syndrome; the past, present and future of anti-obesity medications including new advances in incretin-based therapies which have enabled patients to achieve significant weight loss and improvement in metabolic parameters; and the role of metabolic/bariatric surgery which remains the most effective durable treatment for severe obesity, with high remission rates of metabolic comorbidities like type 2 diabetes. Multimodal approaches involving the combination of lifestyle, medical and surgical advances will revolutionise our approach to treating obesity and metabolic syndrome in the future.

肥胖和代谢综合征:当前的见解和未来的方向。
肥胖和代谢综合征是全球性的健康挑战,显著增加了2型糖尿病、心脑血管疾病和总体死亡率的风险。本文旨在探讨肥胖与代谢综合征之间的关系;抗肥胖药物的过去、现在和未来,包括以肠促胰岛素为基础的疗法的新进展,这些疗法使患者能够实现显著的体重减轻和代谢参数的改善;代谢/减肥手术的作用仍然是最有效的持久治疗严重肥胖,具有高缓解率的代谢合并症,如2型糖尿病。结合生活方式、医学和外科技术进步的多模式治疗方法将彻底改变我们未来治疗肥胖和代谢综合征的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
British journal of hospital medicine
British journal of hospital medicine 医学-医学:内科
CiteScore
1.50
自引率
0.00%
发文量
176
审稿时长
4-8 weeks
期刊介绍: British Journal of Hospital Medicine was established in 1966, and is still true to its origins: a monthly, peer-reviewed, multidisciplinary review journal for hospital doctors and doctors in training. The journal publishes an authoritative mix of clinical reviews, education and training updates, quality improvement projects and case reports, and book reviews from recognized leaders in the profession. The Core Training for Doctors section provides clinical information in an easily accessible format for doctors in training. British Journal of Hospital Medicine is an invaluable resource for hospital doctors at all stages of their career. The journal is indexed on Medline, CINAHL, the Sociedad Iberoamericana de Información Científica and Scopus.
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