{"title":"Substrate Adaptability Enabled by Remote Noncovalent Interactions: How Far Are We?","authors":"Yuhao Zhu, Dr. Ye Zhu","doi":"10.1002/cctc.202500291","DOIUrl":null,"url":null,"abstract":"<p>Remote control of the site-selectivity and stereoselectivity offers new opportunities in accessing novel structures. Covalent templating strategies require an individual rigid tether that matches the geometry of a specific substrate. Recently, methods have been developed to steer the catalytic centers by engaging noncovalent interactions (NCIs) between the substrates and catalysts. Owing to the extended effective distance and flexible directionality of NCIs, it has been discovered that such approaches are adaptable to structural changes of the substrates while preserving the preorganization between substrates and catalysts. This review summarizes the innovation and application of remote control of site-/stereo-selectivity for reactions of arenes featuring NCIs-enabled substrate adaptability.</p>","PeriodicalId":141,"journal":{"name":"ChemCatChem","volume":"17 15","pages":""},"PeriodicalIF":3.9000,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/cctc.202500291","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemCatChem","FirstCategoryId":"92","ListUrlMain":"https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cctc.202500291","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Remote control of the site-selectivity and stereoselectivity offers new opportunities in accessing novel structures. Covalent templating strategies require an individual rigid tether that matches the geometry of a specific substrate. Recently, methods have been developed to steer the catalytic centers by engaging noncovalent interactions (NCIs) between the substrates and catalysts. Owing to the extended effective distance and flexible directionality of NCIs, it has been discovered that such approaches are adaptable to structural changes of the substrates while preserving the preorganization between substrates and catalysts. This review summarizes the innovation and application of remote control of site-/stereo-selectivity for reactions of arenes featuring NCIs-enabled substrate adaptability.
期刊介绍：
With an impact factor of 4.495 (2018), ChemCatChem is one of the premier journals in the field of catalysis. The journal provides primary research papers and critical secondary information on heterogeneous, homogeneous and bio- and nanocatalysis. The journal is well placed to strengthen cross-communication within between these communities. Its authors and readers come from academia, the chemical industry, and government laboratories across the world. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and is supported by the German Catalysis Society.
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