UV Spectroscopy-Based Development and Validation of an Analytical Method for Simultaneous Estimation of Ellagic Acid and Quercetin in Bulk Suspension

IF 1 4区化学 Q4 SPECTROSCOPY

Journal of Applied Spectroscopy Pub Date : 2025-09-11 DOI:10.1007/s10812-025-01985-z

Kabil Malhotra, Kalpana Nagpal

引用次数: 0

Abstract

A UV visible spectroscopic method has been developed for the simultaneous estimation of quercetin and ellagic acid in a suspension. Validation of the developed method was done according to ICH Q2R2 guidelines. Calibration curves (R² > 0.98) were prepared, demonstrating a linear response for the concentration ranges of both drugs. The results indicated high levels of accuracy and precision (all %RSD values <2%). The findings suggest that this method can be readily adopted in routine laboratory settings, facilitating the simultaneous monitoring of drug levels in both bulk and dosage forms.

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紫外光谱法同时测定混悬液中鞣花酸和槲皮素含量的方法建立与验证

建立了紫外可见光谱法同时测定悬浮液中槲皮素和鞣花酸的方法。根据ICH Q2R2指南对所建立的方法进行验证。建立了校正曲线（R2 > 0.98），两种药物的浓度范围呈线性响应。结果显示准确度和精密度较高（所有%RSD值<；2%）。研究结果表明，这种方法可以很容易地在常规实验室环境中采用，便于同时监测散装和剂型的药物水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Applied Spectroscopy SPECTROSCOPY-

CiteScore

1.30

自引率

14.30%

发文量

145

审稿时长

2.5 months

期刊介绍： Journal of Applied Spectroscopy reports on many key applications of spectroscopy in chemistry, physics, metallurgy, and biology. An increasing number of papers focus on the theory of lasers, as well as the tremendous potential for the practical applications of lasers in numerous fields and industries.