Therapeutic effects of chromium supplementation on women with polycystic ovarian syndrome: A systematic review and meta-analysis

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion Pub Date : 2025-04-10 DOI:10.1016/j.endinu.2025.501578

Mohammed Hamsho , Yazan Ranneh , Abdulmannan Fadel

{"title":"Therapeutic effects of chromium supplementation on women with polycystic ovarian syndrome: A systematic review and meta-analysis","authors":"Mohammed Hamsho , Yazan Ranneh , Abdulmannan Fadel","doi":"10.1016/j.endinu.2025.501578","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Polycystic ovarian syndrome (PCOS) has been treated recently with chromium supplementations. However, it is unknown if this dietary supplement has similar effect to metformin.</div></div><div><h3>Aim</h3><div>The aim of this study was to investigate the efficacy of chromium supplementation in women with PCOS.</div></div><div><h3>Methods</h3><div><span>A meta-analysis was conducted using relevant articles obtained from searches of PubMed, </span>Scopus<span>, Embase, and Google Scholar. The mean difference and standardized mean difference were employed to determine the effect size for biochemical parameters.</span></div></div><div><h3>Results</h3><div>A total of 10 randomized controlled trials involving 683 women were included in the analysis. The results indicated that chromium supplementation, as vs a placebo, significantly decreased fasting blood insulin (<em>P</em>  <0.00001), total cholesterol (<em>P</em>  <0.00001), low-density lipoprotein (<em>P</em>  =0.02), malondialdehyde (<em>P</em>  =0.0007), and prolactin (<em>P</em>  =0.02), total antioxidant capacity (<em>P</em>  =0.001). Chromium supplementation was also found to be more effective than metformin in reducing HOMA-IR (<em>P</em>  =0.04).</div></div><div><h3>Conclusion</h3><div>Chromium picolinate supplementation at a dosage of 200<!--> <span>μg may provide benefits similar to metformin with regard to FBG<span>, FBI, ovulation, and pregnancy incidence, with fewer side effects in patients with PCOS. Further experiments are still required to draw effective dietary guidelines related to chromium.</span></span></div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 8","pages":"Article 501578"},"PeriodicalIF":0.0000,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrinologia, Diabetes y Nutricion","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2530016425000394","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Nursing","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Polycystic ovarian syndrome (PCOS) has been treated recently with chromium supplementations. However, it is unknown if this dietary supplement has similar effect to metformin.

Aim

The aim of this study was to investigate the efficacy of chromium supplementation in women with PCOS.

Methods

A meta-analysis was conducted using relevant articles obtained from searches of PubMed, Scopus, Embase, and Google Scholar. The mean difference and standardized mean difference were employed to determine the effect size for biochemical parameters.

Results

A total of 10 randomized controlled trials involving 683 women were included in the analysis. The results indicated that chromium supplementation, as vs a placebo, significantly decreased fasting blood insulin (P = 0.01), triglyceride (P < 0.00001), total cholesterol (P < 0.00001), very low-density lipoprotein (P < 0.00001), low-density lipoprotein (P = 0.0003), high sensitivity C-reactive protein (P = 0.02), malondialdehyde (P = 0.007), follicle stimulating hormone (P = 0.0007), and prolactin (P = 0.01), and increased the Quantitative Insulin Sensitivity Check Index (P = 0.02), total antioxidant capacity (P < 0.0001), and ovulation incidence (P = 0.001). Chromium supplementation was also found to be more effective than metformin in reducing HOMA-IR (P < 0.00001), and luteinizing hormone (P = 0.04).

Conclusion

Chromium picolinate supplementation at a dosage of 200 μg may provide benefits similar to metformin with regard to FBG, FBI, ovulation, and pregnancy incidence, with fewer side effects in patients with PCOS. Further experiments are still required to draw effective dietary guidelines related to chromium.

查看原文本刊更多论文

补充铬对女性多囊卵巢综合征的治疗效果：系统回顾和荟萃分析

背景：最近，铬补充剂被用于治疗多囊卵巢综合征（PCOS）。然而，尚不清楚这种膳食补充剂是否具有与二甲双胍相似的效果。目的本研究的目的是探讨铬补充剂对多囊卵巢综合征妇女的疗效。方法采用PubMed、Scopus、Embase和谷歌Scholar检索的相关文章进行meta分析。采用均数差和标准化均数差确定生化参数的效应大小。结果共纳入10项随机对照试验，涉及683名女性。结果表明，与安慰剂相比，添加铬显著降低空腹血胰岛素（P = 0.01）、甘油三酯（P < 0.00001）、总胆固醇（P < 0.00001）、极低密度脂蛋白（P < 0.00001）、低密度脂蛋白（P = 0.0003）、高敏c反应蛋白（P = 0.02）、丙二醛（P = 0.007）、促卵泡激素（P = 0.0007）和催乳素（P = 0.01）。增加了胰岛素敏感性定量检查指数（P = 0.02）、总抗氧化能力（P < 0.0001）和排卵发生率（P = 0.001）。铬补充剂也被发现在降低HOMA-IR （P < 0.00001）和黄体生成素（P = 0.04）方面比二甲双胍更有效。结论补充200 μg吡啶甲酸铬对PCOS患者的FBG、FBI、排卵和妊娠发生率的影响与二甲双胍相似，且副作用更小。还需要进一步的实验来制定与铬有关的有效膳食指南。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Endocrinologia, Diabetes y Nutricion Nursing-Nutrition and Dietetics

CiteScore

2.10

自引率

0.00%

发文量

169

审稿时长

35 days

期刊介绍： Endocrinología, Diabetes y Nutrición is the official journal of the Spanish Society of Endocrinology and Nutrition (Sociedad Española de Endocrinología y Nutrición, SEEN) and the Spanish Society of Diabetes (Sociedad Española de Diabetes, SED), and was founded in 1954. The aim of the journal is to improve knowledge and be a useful tool in practice for clinical and laboratory specialists, trainee physicians, researchers, and nurses interested in endocrinology, diabetes, nutrition and related disciplines. It is an international journal published in Spanish (print and online) and English (online), covering different fields of endocrinology and metabolism, including diabetes, obesity, and nutrition disorders, as well as the most relevant research produced mainly in Spanish language territories. The quality of the contents is ensured by a prestigious national and international board, and by a selected panel of specialists involved in a rigorous peer review. The result is that only manuscripts containing high quality research and with utmost interest for clinicians and professionals related in the field are published. The Journal publishes Original clinical and research articles, Reviews, Special articles, Clinical Guidelines, Position Statements from both societies and Letters to the editor. Endocrinología, Diabetes y Nutrición can be found at Science Citation Index Expanded, Medline/PubMed and SCOPUS.