Tunable pH-Responsive Release Kinetics of Doxorubicin from Iron Oxide-Loaded Cellulose Acetate Nanofibers for Localized Drug Delivery

IF 4.7 2区化学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Polymer Materials Pub Date : 2025-09-11 DOI:10.1021/acsapm.5c02631

Dayae Kang, , , Ji Ha Lee*, , , Azeem Ullah, , , Gopiraman Mayakrishnan, , , Chieri Inada, , , Tomoki Nishimura, , , Jungsoon Lee*, , and , Ick Soo Kim*,

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引用次数: 0

Abstract

Cellulose acetate (CA) nanofibers incorporating Fe₂O₃ and Fe₃O₄ nanoparticles were fabricated via electrospinning for the pH-responsive delivery of doxorubicin (DOX). The nanofiber morphology, surface wettability, chemical composition, and crystallinity were analyzed using FE-SEM, water contact angle measurements, FT-IR spectroscopy, and XRD, respectively. The incorporation of iron oxide nanoparticles altered the fiber diameter while maintaining the overall structural integrity of the CA matrix. The incorporation of iron oxide significantly enhanced DOX loading efficiency, with 2 wt % Fe₃O₄ nanofibers achieving the highest loading capacity. Drug release studies revealed sustained DOX release under physiological conditions (pH 7.2), governed by diffusion mechanisms, and accelerated release under acidic conditions (pH 5.0), associated with polymer relaxation and erosion. Nanofibers containing 2 wt % Fe₂O₃ and 2 wt % Fe₃O₄ exhibited optimal pH-responsive release profiles, maintained structural stability, and demonstrated favorable morphology. Cytotoxicity assays using CT26 cells confirmed the biological activity of DOX released from the nanofibers, demonstrating significant cancer cell suppression under tumor-mimicking acidic conditions.

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氧化铁负载醋酸纤维素纳米纤维对阿霉素局部释放的ph响应动力学研究

采用静电纺丝法制备了含Fe2O3和Fe3O4纳米颗粒的醋酸纤维素纳米纤维，用于ph响应递送阿霉素（DOX）。利用FE-SEM、水接触角测量、FT-IR光谱和XRD分析了纳米纤维的形貌、表面润湿性、化学成分和结晶度。氧化铁纳米颗粒的掺入改变了纤维直径，同时保持了CA基体的整体结构完整性。氧化铁的掺入显著提高了DOX的负载效率，2 wt %的Fe3O4纳米纤维达到了最高的负载能力。药物释放研究显示，DOX在生理条件下（pH 7.2）持续释放，受扩散机制控制；在酸性条件下（pH 5.0）加速释放，与聚合物松弛和侵蚀有关。含有2 wt % Fe2O3和2 wt % Fe3O4的纳米纤维表现出最佳的ph响应释放曲线，保持结构稳定性，并表现出良好的形貌。使用CT26细胞进行的细胞毒性试验证实了纳米纤维释放的DOX的生物活性，显示出在模拟肿瘤的酸性条件下对癌细胞的显著抑制。

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来源期刊

ACS Applied Polymer Materials Multiple-

CiteScore

7.20

自引率

6.00%

发文量

810

期刊介绍： ACS Applied Polymer Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics, and biology relevant to applications of polymers. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates fundamental knowledge in the areas of materials, engineering, physics, bioscience, polymer science and chemistry into important polymer applications. The journal is specifically interested in work that addresses relationships among structure, processing, morphology, chemistry, properties, and function as well as work that provide insights into mechanisms critical to the performance of the polymer for applications.