Investigation of the protective efficacy of Caesalpinia sappan and spirulina against ethanol-induced experimental rat gastritis model.

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Acta cirurgica brasileira Pub Date : 2025-09-19 eCollection Date: 2025-01-01 DOI:10.1590/acb406725

İdris Oruç, Zelal Karakoç, Filiz Akduman, Zeynep Oruç, Nazan Baksi, Muzaffer Aydin Ketani

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Abstract

Purpose: To evaluate the protective effect of Caesalpinia sappan and spirulina against gastritis and determine changes in the expression of CD8, CD68, and major histocompatibility complex (MHC) molecules.

Methods: Gastritis was induced in 24 female Wistar albino rats on the first day using ethanol. The treatment groups were given C. sappan (250 mg/kg) and spirulina (400 mg/kg) using oral gavage for five days. Blood and stomach tissue samples of the mice were analyzed.

Results: Caesalpinia sappan and spirulina increased CD8 and CD68 expression and tumor necrosis factor-alpha levels thereby decreasing the severity of inflammation. It was found that they simultaneously decreased MHC I and MHC II expressing cells, increased superoxide dismutase levels, whereas malondialdehyde, and myeloperoxidase levels decreased in the treatment group.

Conclusion: This study revealed that C. sappan and spirulina can protect gastric mucosa by reducing oxidative stress and inflammation.

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参、螺旋藻对乙醇性大鼠胃炎模型保护作用的研究。

目的：探讨螺旋藻和太子参对胃炎的保护作用，探讨CD8、CD68及主要组织相容性复合体（MHC）分子表达的变化。方法：24只雌性Wistar白化大鼠第1天用乙醇诱导胃炎。给药组分别给予人参（250 mg/kg）、螺旋藻（400 mg/kg）灌胃5 d。对小鼠的血液和胃组织样本进行分析。结果：参、螺旋藻可提高CD8、CD68表达及肿瘤坏死因子α水平，减轻炎症的严重程度。结果发现，它们同时降低了MHC I和MHC II表达细胞，增加了超氧化物歧化酶水平，而治疗组丙二醛和髓过氧化物酶水平降低。结论：本研究揭示了螺旋藻和菝葜具有降低氧化应激和炎症的保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Acta cirurgica brasileira

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