Chronic Treatment with Panax ginseng and Angelica keiskei Decreases Blood Pressure and Improves Endothelial Function in Ovariectomized Rats.

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Arquivos brasileiros de cardiologia Pub Date : 2025-09-19 eCollection Date: 2025-01-01 DOI:10.36660/abc.20240685

Nayara Formenton da Silva, Luis Henrique Oliveira de Moraes, Camila Pereira Sabadini, Rita Cristina Cotta Alcântara, Patrícia Corrêa Dias, Gerson Jhonatan Rodrigues

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Abstract

Background: Menopause is a natural physiological process that can impact various systems and organs, often leading to increased blood pressure. The combination of Panax ginseng and Angelica keiskei (Pg + Ak) is a formulation known to improve vascular function.

Objective: This study aimed to evaluate the in vivo effects of these combined plants on cardiovascular parameters in female rats experiencing menopause induced by ovariectomy.

Methods: Twenty-four 70-day-old female Wistar rats were randomly assigned to three groups: sham-operated (Sham), ovariectomized (OVX), and ovariectomized with Pg + Ak treatment (OVX + Pg + Ak). The rats in the Pg + Ak treatment group received an intraperitoneal injection of 100 mg/kg/day for two weeks. Blood pressure was measured using tail plethysmography, and endothelial function was assessed through vascular reactivity tests.

Results: At the end of the treatment, mean blood pressure in the SH group was lower than in the control group (OVX), and the Pg + Ak treatment improved the endothelial dysfunction caused by ovariectomy. This was evident in the restored endothelium-dependent vasodilation in the aortic rings of the OVX rats treated with Pg + Ak compared to untreated OVX rats.

Conclusions: Our findings suggest that the Pg + Ak combination effectively reduces blood pressure and reverses endothelial dysfunction in ovariectomized rats.

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人参和当归慢性治疗可降低去卵巢大鼠血压和改善内皮功能。

背景：更年期是一个自然的生理过程，可以影响到各个系统和器官，经常导致血压升高。人参和当归（Pg + Ak）的组合是一种已知的改善血管功能的配方。目的：本研究旨在评价这些植物组合对卵巢切除后绝经大鼠心血管参数的体内影响。方法：将24只70日龄雌性Wistar大鼠随机分为假手术组（Sham）、去卵巢组（OVX）和去卵巢加Pg + Ak组（OVX + Pg + Ak）。Pg + Ak治疗组大鼠腹腔注射100 mg/kg/d，连续2周。采用尾容积描记术测量血压，通过血管反应性试验评估内皮功能。结果：治疗结束时，SH组平均血压低于对照组（OVX）， Pg + Ak治疗可改善卵巢切除术后内皮功能障碍。与未治疗的OVX大鼠相比，Pg + Ak治疗的OVX大鼠主动脉环内皮依赖性血管舒张恢复明显。结论：Pg + Ak联合用药可有效降低去卵巢大鼠血压，逆转内皮功能障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Arquivos brasileiros de cardiologia

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