Use of primary oral vancomycin prophylaxis to stem an outbreak of Clostridioides difficile infection in intensive care patients.

Abstract

Over 5.5-months, hospital-onset Clostridioides difficile infections (HO-CDI) in intensive care units (ICUs) increased from a baseline 6.2 cases to 19.1 cases per 10,000 patient-days (P = .03). Primary oral vancomycin prophylaxis (OVP) to select patients was initiated; subsequently there were 5.7 cases /10,000 patient-days (P = .05). Primary OVP curbed an outbreak of HO-CDI.