Transcatheter Aortic Valve Implantation in West Africa: A Severe Aortic Stenosis Case Report.

Q4 Medicine
West African journal of medicine Pub Date : 2025-04-30
T Majekodunmi, O K Oguntuga
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Abstract

Background and objectives: Aortic valve stenosis (AoS) is the most common valvular pathology in the elderly, many of whom are ineligible or high-risk for surgery due to comorbidities. Transcatheter Aortic Valve Implantation (TAVI) was developed as a less invasive alternative to Surgical Aortic Valve Replacement (SAVR) for patients with severe AoS. Its efficacy was first demonstrated in the landmark PARTNER trial, which compared TAVI to medical therapy in ineligible SAVR patients. Subsequent studies have validated its use in intermediate and low-risk groups. Despite its growing adoption, there has yet to be a report of a successful TAVI procedure in West Africa.

Methods: The procedure involved transcatheter aortic valve implantation using radial and femoral arterial access. A 14Fr Python sheath was introduced after vessel dilation, and the valve was crimped and positioned in the aortic annulus under fluoroscopic guidance. Serial aortograms confirmed accurate placement, and haemostasis was achieved using a Proglide suture, protamine administration, and manual pressure. The patient was transferred to the ICU post-procedure for monitoring.

Results: The patient's post-procedure imaging showed a well-seated valve with trivial central aortic regurgitation, no paravalvular leak, and an insignificant gradient of 12.25 mmHg. The patient remained stable, resumed anticoagulation, and was discharged with a follow-up scheduled in one week.

Conclusions: This case report details the successful prosthetic aortic valve implantation in an 83-year-old high-risk surgical candidate with hypertension and bilateral knee replacements. It marks a significant step toward adopting less invasive valvular heart disease management approaches in the region.

经导管主动脉瓣植入术在西非:一个严重的主动脉狭窄病例报告。
背景与目的:主动脉瓣狭窄(Aortic valve stenosis, AoS)是老年人最常见的瓣膜病理,其中许多老年人由于合共病而不适合或高危手术。经导管主动脉瓣植入术(TAVI)是一种创伤较小的替代手术主动脉瓣置换术(SAVR)治疗严重AoS患者的方法。具有里程碑意义的PARTNER试验首次证明了TAVI的疗效,该试验将TAVI与不符合条件的SAVR患者的药物治疗进行了比较。随后的研究证实了它在中低危人群中的应用。尽管越来越多的人采用TAVI,但目前还没有关于西非TAVI手术成功的报道。方法:经导管主动脉瓣植入术采用桡动脉和股动脉通道。血管扩张后引入14Fr Python鞘,在透视引导下卷曲瓣膜置于主动脉环内。连续主动脉造影证实了准确的位置,使用Proglide缝线、鱼精蛋白和手压止血。术后转ICU监护。结果:患者术后影像学显示瓣膜位置良好,主动脉中心有轻微反流,无瓣旁漏,梯度为12.25 mmHg。患者病情稳定,恢复抗凝治疗,一周后随访出院。结论:本病例报告详细介绍了一例83岁高血压和双侧膝关节置换术的高危手术候选人的成功人工主动脉瓣植入术。这标志着该地区朝着采用侵入性较小的瓣膜性心脏病管理方法迈出了重要一步。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
West African journal of medicine
West African journal of medicine Medicine-Medicine (all)
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