Influence of Ancestral and Geographic Factors on Intracerebral Hemorrhage Risks Among Africans and Americans.

IF 8.9 1区医学 Q1 CLINICAL NEUROLOGY

Stroke Pub Date : 2025-09-24 DOI:10.1161/STROKEAHA.125.051911

Paul Olowoyo, Osahon J Asowata, Onoja Akpa, Mary E Comeau, Christopher D Anderson, Jacob L McCauley, Joshua Akinyemi, Morenikeji Komolafe, Albert Akpalu, Oyedunni Arulogun, Fred Sarfo, Reginald Obiako, Godwin Osaigbovo, Adekunle Fakunle, Olufunmilola Macaulay, Olayinka Adebajo, Godwin Ogbole, Akinkunmi Paul Okekunle, Arti Singh, Innocent Chukwuonye, Oladotun Olalusi, Ayomide Owolabi, Atinuke Agunloye, Yaw Mensah, Carolyn Jenkins, Mayowa Ogunronbi, Osimhiarherhuo Adeleye, Ezinne Uvere, Kolawole Wahab, Philip Ibinaiye, Okechukwu Ogah, Lambert Appiah, Michael B Fawale, Samuel Diala, Hemant Tiwari, Rufus Akinyemi, Donna K Arnett, Carl D Langefeld, Bruce Ovbiagele, Daniel Woo, Mayowa Owolabi

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引用次数: 0

Abstract

Background: We investigated whether risk factors for intracerebral hemorrhage (ICH) among indigenous Africans (IA) would vary in prevalence and effect compared with self-reported African, Hispanic, and White Americans by comparing data from 2 independent population-based case-control studies conducted in West Africa and the United States.

Methods: We compared ICH risk factors common to the SIREN (Stroke Investigative Research and Educational Network: 1100 case-control pairs) and the ERICH (Ethnic/Racial Variation of Intracerebral Hemorrhage: 999 case-control pairs Black participants, 998 case-control pairs, Hispanic Americans, 1000 case-control pairs, White Americans) studies. Ethnicity/Race was self-reported. The effect measure of interest is the odds ratio (OR). To test for differences in the effects of the risk factors between the SIREN IA study population and each of the ERICH study populations, a test for heterogeneity was computed using the R program, metagen (version 4.9-6).

Results: ICH occurred at a younger age among IA (54.3±13.4 years), Balck participants (58.0±12.7), and Hispanic Americans (58.9±14.3), compared with White Americans (69.1±13.9). The largest distinction was for hypertension, where IA exhibited a much larger risk of ICH than the American study population (OR, 67.02 [95% CI, 33.30-134.85]), Black population (OR, 3.71 [95% CI, 2.53-5.44]); Hispanic (OR, 3.55 [95% CI, 2.54-4.92]), and White population (OR, 2.69 [95% CI, 1.95-3.69]). Current alcohol use exhibited increased risk in IA (OR, 2.24 [95% CI, 1.36-3.67]), but not in Black participants (OR, 0.63 [95% CI, 0.46-0.86]), Hispanic (OR, 0.87 [95% CI, 0.65-1.17]), and White Americans (OR, 0.51 [95% CI, 0.38-0.69]).

Conclusions: Identical or comparable risk factors do not consistently result in the same disease risk across different cultures and regions. Therefore, to improve our understanding of the genetic determinants and biological pathways driving ICH risk, it is crucial to study multiple populations, including IA, while accounting for the influence of environmental and social factors.

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祖源和地理因素对非洲人和美洲人脑出血风险的影响

背景：我们通过比较在西非和美国进行的两项独立的基于人群的病例对照研究的数据，调查了土著非洲人（IA）脑出血（ICH）的危险因素在患病率和效果上是否会与自我报告的非洲人、西班牙裔和白人美国人不同。方法：我们比较了卒中调查研究和教育网络（卒中调查研究和教育网络：1100对病例对照）和ERICH（脑出血的种族/种族差异：999对病例对照）研究中常见的脑出血危险因素黑人参与者，998对病例对照，西班牙裔美国人，1000对病例对照，白人美国人)。民族/种族是自我报告的。兴趣的效果度量是比值比（OR）。为了检验SIREN IA研究人群和每个ERICH研究人群之间危险因素影响的差异，使用R程序metagen（版本4.9-6）计算异质性检验。结果：在IA（54.3±13.4岁）、黑人（58.0±12.7岁）和西班牙裔美国人（58.9±14.3岁）中，脑出血发生的年龄较年轻，而白人（69.1±13.9岁）。最大的区别是高血压，IA人群患脑出血的风险远高于美国研究人群（OR, 67.02 [95% CI, 33.30-134.85]），黑人人群（OR, 3.71 [95% CI, 2.53-5.44]）；西班牙裔（OR, 3.55 [95% CI, 2.54-4.92]）和白人（OR, 2.69 [95% CI, 1.95-3.69]）。当前饮酒增加了IA的风险（OR, 2.24 [95% CI, 1.36-3.67]），但在黑人参与者（OR, 0.63 [95% CI, 0.46-0.86]）、西班牙裔参与者（OR, 0.87 [95% CI, 0.65-1.17]）和美国白人参与者（OR, 0.51 [95% CI, 0.38-0.69]）中没有增加风险。结论：在不同文化和地区，相同或可比较的风险因素并不总是导致相同的疾病风险。因此，为了提高我们对驱动ICH风险的遗传决定因素和生物学途径的理解，在考虑环境和社会因素影响的同时，研究包括IA在内的多个人群至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Stroke 医学-临床神经学

CiteScore

13.40

自引率

6.00%

发文量

2021

审稿时长

3 months

期刊介绍： Stroke is a monthly publication that collates reports of clinical and basic investigation of any aspect of the cerebral circulation and its diseases. The publication covers a wide range of disciplines including anesthesiology, critical care medicine, epidemiology, internal medicine, neurology, neuro-ophthalmology, neuropathology, neuropsychology, neurosurgery, nuclear medicine, nursing, radiology, rehabilitation, speech pathology, vascular physiology, and vascular surgery. The audience of Stroke includes neurologists, basic scientists, cardiologists, vascular surgeons, internists, interventionalists, neurosurgeons, nurses, and physiatrists. Stroke is indexed in Biological Abstracts, BIOSIS, CAB Abstracts, Chemical Abstracts, CINAHL, Current Contents, Embase, MEDLINE, and Science Citation Index Expanded.