{"title":"Neurobrucellosis and Multiple Sclerosis: Cause, Confounder, or Coincidence?","authors":"Burak Kocaaga, Nermin Celik, Ozge Kaba, Melis Deniz, Nurhayat Yakut","doi":"10.1590/0037-8682-0154-2024","DOIUrl":null,"url":null,"abstract":"<p><p>We report the case of a 17-year-old girl who was initially diagnosed with multiple sclerosis based on clinical and radiological findings and later confirmed to have neurobrucellosis via cerebrospinal fluid Brucella polymerase chain reaction positivity. Magnetic resonance imaging revealed demyelinating lesions consistent with multiple sclerosis, and Brucella infection due to epidemiological exposure was suspected. To the best of our knowledge, this is the first pediatric report of coexisting neurobrucellosis and multiple sclerosis. It underscores the diagnostic challenges in distinguishing between infectious and autoimmune demyelinating disorders, particularly in endemic regions, and highlights the importance of a comprehensive evaluation of atypical presentations.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":"e01542025"},"PeriodicalIF":2.3000,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455749/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista da Sociedade Brasileira de Medicina Tropical","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1590/0037-8682-0154-2024","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PARASITOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
We report the case of a 17-year-old girl who was initially diagnosed with multiple sclerosis based on clinical and radiological findings and later confirmed to have neurobrucellosis via cerebrospinal fluid Brucella polymerase chain reaction positivity. Magnetic resonance imaging revealed demyelinating lesions consistent with multiple sclerosis, and Brucella infection due to epidemiological exposure was suspected. To the best of our knowledge, this is the first pediatric report of coexisting neurobrucellosis and multiple sclerosis. It underscores the diagnostic challenges in distinguishing between infectious and autoimmune demyelinating disorders, particularly in endemic regions, and highlights the importance of a comprehensive evaluation of atypical presentations.
期刊介绍：
The Journal of the Brazilian Society of Tropical Medicine (JBSTM) isan official journal of the Brazilian Society of Tropical Medicine) with open access. It is amultidisciplinary journal that publishes original researches related totropical diseases, preventive medicine, public health, infectious diseasesand related matters. Preference for publication will be given to articlesreporting original observations or researches. The journal has a peer-reviewsystem for articles acceptance and its periodicity is bimonthly. The Journalof the Brazilian Society of Tropical Medicine is published in English.The journal invites to publication Major Articles, Editorials, Reviewand Mini-Review Articles, Short Communications, Case Reports, TechnicalReports, Images in Infectious Diseases, Letters, Supplements and Obituaries.
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