Complex Wound Reconstruction in a Patient With Ehlers-Danlos Syndrome.

IF 1.8 Q3 SURGERY

Plastic and Reconstructive Surgery Global Open Pub Date : 2025-09-22 eCollection Date: 2025-09-01 DOI:10.1097/GOX.0000000000007120

Sohayla Rostami, Tomer Lagziel, Stephanie Lynne Martinez, Qingwen Kawaji, Charles Scott Hultman, Mark E Lavallee

{"title":"Complex Wound Reconstruction in a Patient With Ehlers-Danlos Syndrome.","authors":"Sohayla Rostami, Tomer Lagziel, Stephanie Lynne Martinez, Qingwen Kawaji, Charles Scott Hultman, Mark E Lavallee","doi":"10.1097/GOX.0000000000007120","DOIUrl":null,"url":null,"abstract":"<p><p>Ehlers-Danlos syndrome (EDS) is a hereditary condition marked by collagen defects leading to tissue fragility throughout various body systems. One notable challenge for patients with EDS is compromised wound healing due to connective tissue fragility. This study described the case of a 53-year-old man with classical type EDS, presenting with a significant wound over his left knee, following numerous complications after a patellar tendon rupture. Traditional healing methods, including a gastrocnemius flap, were of limited benefit due to the patient's EDS condition. A novel surgical approach, involving the use of a split-thickness skin graft combined with the Recell Autologous Skin Cell Harvesting Device, resulted in successful wound healing. Ten months postsurgery, the patient demonstrated excellent graft adherence without any complications. This case indicates the potential benefits of the split-thickness skin graft and Recell method for patients with EDS, offering an effective treatment modality for significant wound healing challenges in this population.</p>","PeriodicalId":20149,"journal":{"name":"Plastic and Reconstructive Surgery Global Open","volume":"13 9","pages":"e7120"},"PeriodicalIF":1.8000,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12453333/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Plastic and Reconstructive Surgery Global Open","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/GOX.0000000000007120","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"SURGERY","Score":null,"Total":0}

引用次数: 0

Abstract

Ehlers-Danlos syndrome (EDS) is a hereditary condition marked by collagen defects leading to tissue fragility throughout various body systems. One notable challenge for patients with EDS is compromised wound healing due to connective tissue fragility. This study described the case of a 53-year-old man with classical type EDS, presenting with a significant wound over his left knee, following numerous complications after a patellar tendon rupture. Traditional healing methods, including a gastrocnemius flap, were of limited benefit due to the patient's EDS condition. A novel surgical approach, involving the use of a split-thickness skin graft combined with the Recell Autologous Skin Cell Harvesting Device, resulted in successful wound healing. Ten months postsurgery, the patient demonstrated excellent graft adherence without any complications. This case indicates the potential benefits of the split-thickness skin graft and Recell method for patients with EDS, offering an effective treatment modality for significant wound healing challenges in this population.

Abstract Image

查看原文本刊更多论文

ehers - danlos综合征患者的复杂伤口重建。

ehers - danlos综合征（EDS）是一种遗传性疾病，其特征是胶原蛋白缺陷导致各种身体系统的组织脆弱。对于EDS患者来说，一个值得注意的挑战是由于结缔组织的脆弱性导致伤口愈合受损。本研究描述了一例53岁男性经典型EDS，表现为左膝明显伤口，髌腱断裂后出现多种并发症。传统的治疗方法，包括腓肠肌皮瓣，由于患者的EDS状况，效益有限。一种新的手术方法，包括使用裂厚皮肤移植物结合Recell自体皮肤细胞收集装置，导致伤口成功愈合。术后10个月，患者表现出良好的移植物粘附性，无任何并发症。该病例显示了劈裂厚度皮肤移植和Recell方法对EDS患者的潜在益处，为这一人群的重大伤口愈合挑战提供了一种有效的治疗方式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Plastic and Reconstructive Surgery Global Open SURGERY-

CiteScore

2.20

自引率

13.30%

发文量

1584

审稿时长

10 weeks

期刊介绍： Plastic and Reconstructive Surgery—Global Open is an open access, peer reviewed, international journal focusing on global plastic and reconstructive surgery.Plastic and Reconstructive Surgery—Global Open publishes on all areas of plastic and reconstructive surgery, including basic science/experimental studies pertinent to the field and also clinical articles on such topics as: breast reconstruction, head and neck surgery, pediatric and craniofacial surgery, hand and microsurgery, wound healing, and cosmetic and aesthetic surgery. Clinical studies, experimental articles, ideas and innovations, and techniques and case reports are all welcome article types. Manuscript submission is open to all surgeons, researchers, and other health care providers world-wide who wish to communicate their research results on topics related to plastic and reconstructive surgery. Furthermore, Plastic and Reconstructive Surgery—Global Open, a complimentary journal to Plastic and Reconstructive Surgery, provides an open access venue for the publication of those research studies sponsored by private and public funding agencies that require open access publication of study results. Its mission is to disseminate high quality, peer reviewed research in plastic and reconstructive surgery to the widest possible global audience, through an open access platform. As an open access journal, Plastic and Reconstructive Surgery—Global Open offers its content for free to any viewer. Authors of articles retain their copyright to the materials published. Additionally, Plastic and Reconstructive Surgery—Global Open provides rapid review and publication of accepted papers.