Procalcitonin and C-reactive protein as biomarkers for diagnosing and assessing the severity of acute cholecystitis.

IF 1.6 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine Pub Date : 2025-09-11 eCollection Date: 2025-01-01 DOI:10.1515/med-2025-1258

Qisheng Hou, Huayu Li, Cheng Liu, Yujia Sun, Bo Wang, Hui Xiong, Si Liu

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引用次数: 0

Abstract

Background: Acute cholecystitis (AC) is a common condition in emergency departments (EDs), where timely diagnosis and severity assessment are critical for treatment decisions and outcome prediction.

Methods: This study included 194 patients with AC to evaluate the diagnostic and severity-grading performance of procalcitonin (PCT) and C-reactive protein (CRP). Receiver operating characteristic (ROC) curve analysis was used to determine optimal cut-off values for discriminating between severity grades according to the Tokyo Guidelines.

Results: Elevated levels of PCT and CRP were observed in 73.2 and 67% of cases, respectively. PCT demonstrated a sensitivity of 75.6% and specificity of 64.8% at a cut-off value of ≤ 0.595 ng/mL for distinguishing grade I from grades II to III. For differentiating grade III from grades I to II, PCT showed a sensitivity of 62.5% and specificity of 92.1% at a cut-off value of ≥5.095 ng/mL. Similarly, CRP had a sensitivity of 82.9% and specificity of 64.8% at a cut-off value of ≤78 mg/L for grade I versus grades II to III, and a sensitivity of 62.5% and specificity of 69.7% at a cut-off value of ≥82.5 mg/L for grade III versus grades I to II.

Conclusion: Both PCT and CRP are valuable biomarkers for diagnosing AC and assessing its severity.

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降钙素原和c反应蛋白作为诊断和评估急性胆囊炎严重程度的生物标志物。

背景：急性胆囊炎（AC）是急诊科（EDs）的常见病，及时诊断和严重程度评估对治疗决策和预后预测至关重要。方法：本研究纳入194例AC患者，评价降钙素原（PCT）和c反应蛋白（CRP）的诊断和严重程度分级性能。采用受试者工作特征（ROC）曲线分析，根据东京指南确定区分严重程度等级的最佳临界值。结果：PCT和CRP水平升高分别占73.2%和67%。在截断值≤0.595 ng/mL时，PCT区分I级和II至III级的敏感性为75.6%，特异性为64.8%。在临界值≥5.095 ng/mL时，PCT鉴别III级和I至II级的敏感性为62.5%，特异性为92.1%。同样，c反应蛋白在I级与II至III级的临界值≤78 mg/L时的敏感性为82.9%，特异性为64.8%，在III级与I至II级的临界值≥82.5 mg/L时的敏感性为62.5%，特异性为69.7%。结论：PCT和CRP是诊断AC和评估其严重程度的有价值的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Medicine Medicine-General Medicine

CiteScore

3.00

自引率

0.00%

发文量

153

审稿时长

20 weeks

期刊介绍： Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.