Ameliorative effect of spirulina on methotrexate-induced male fertility and oxidative stress in rats.

IF 1 Q3 VETERINARY SCIENCES

Open Veterinary Journal Pub Date : 2025-06-01 Epub Date: 2025-06-30 DOI:10.5455/OVJ.2025.v15.i6.25

Noran Ibrahim Salah, Reda M Abd El-Aziz, Sameh Elnabtity, Wageh Sobhy Darwish

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引用次数: 0

Abstract

Background: Methotrexate is a chemotherapy drug that is used despite having several toxic effects. Spirulina is commonly consumed as a food supplement because of its antioxidant, antiinflammatory, and other beneficial effects. Aim: The present study was conducted to investigate the adverse effects of MTX on male sex hormones and subsequently its effects on oxidant/antioxidant status. The ameliorative effects of spirulina against such MTX-induced adverse effects were also evaluated.

Methods: Forty male rats were randomly divided into four groups: control, spirulina, MTX, and MTX + spirulina groups. The levels of testosterone (free and total), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and prolactin hormone were evaluated as biochemical markers of MTX-induced infertility. Malondialdehyde (MDA) and total antioxidant capacity (TAC) levels were assayed in liver tissue as oxidative stress markers.

Results: The results obtained from the current study showed that Spirulina improved the adverse effects of MTX on testosterone (free and total), LH, FSH, MDA, and TAC.

Conclusions: The current study indicated that spirulina can be used to ameliorate MTX-induced adverse effects on male infertility and oxidative stress.

Abstract Image

查看原文本刊更多论文

螺旋藻对甲氨蝶呤诱导大鼠雄性生殖能力和氧化应激的改善作用。

背景：甲氨蝶呤是一种化疗药物，尽管有几种毒性作用。由于螺旋藻具有抗氧化、抗炎和其他有益作用，它通常被用作食品补充剂。目的：本研究旨在探讨甲氨蝶呤对雄性性激素的不良影响及其对氧化/抗氧化状态的影响。螺旋藻对甲氨蝶呤诱导的不良反应的改善作用也进行了评价。方法：40只雄性大鼠随机分为4组：对照组、螺旋藻组、MTX组、MTX +螺旋藻组。睾酮（游离和总）、促黄体生成素（LH）、促卵泡激素（FSH）和催乳素水平作为mtx诱导不孕的生化指标。以丙二醛（MDA）和总抗氧化能力（TAC）水平作为氧化应激标志物。结果：本研究结果显示，螺旋藻改善了MTX对游离和总睾酮、LH、FSH、MDA和TAC的不良反应。结论：螺旋藻可改善mtx诱导的男性不育症和氧化应激的不良反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Veterinary Journal VETERINARY SCIENCES-

CiteScore

1.40

自引率

0.00%

发文量

112

审稿时长

12 weeks

期刊介绍： Open Veterinary Journal is a peer-reviewed international open access online and printed journal that publishes high-quality original research articles. reviews, short communications and case reports dedicated to all aspects of veterinary sciences and its related subjects. Research areas include the following: Infectious diseases of zoonotic/food-borne importance, applied biochemistry, parasitology, endocrinology, microbiology, immunology, pathology, pharmacology, physiology, epidemiology, molecular biology, immunogenetics, surgery, ophthalmology, dermatology, oncology and animal reproduction. All papers are peer-reviewed. Moreover, with the presence of well-qualified group of international referees, the process of publication will be done meticulously and to the highest standards.