Aging, Alzheimer's disease, and stroke: A 25-year longitudinal analysis of U.S. mortality trends.

IF 3.1 3区 医学 Q2 NEUROSCIENCES
Muhammad Faizan Ali, Husnain Ahmad, Mohamed Fawzi Hemida, Muhammad Faizan Tahir, Talha Qadeer, Sana Rasheed, Zarwa Rashid, Mohammad Hamza Bin Abdul Malik, Ashraf Ahmed, Alexander Morden, Muhammad Abdullah Naveed, Himaja Dutt Chigurupati, Sivaram Neppala
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Abstract

BackgroundAlzheimer's disease (AD) and stroke, both of which are age-related conditions, exhibit common risk factors such as hypertension, smoking, diabetes, and the APOE ε4 genotype, which frequently coexist in older adults.ObjectiveThis study investigates disparities in stroke-related mortality among AD patients, categorized by sex, race/ethnicity, and geographic region.MethodsThe age-adjusted mortality rates (AAMRs) per 100,000 for adults 65 and older were sourced from the CDC WONDER database using ICD codes for AD (G30) and stroke (I60-I61, I63-I64, I69). Joinpoint regression estimated the Annual Percent Change (APC) and Average Annual Percent Change (AAPC), with statistical significance at p < 0.0001.ResultsFrom 1999 to 2023, there were 154,323 deaths related to strokes in AD patients, primarily occurring in nursing homes (53.4%). The AAMRs decreased from 19.4 in 1999 to 10.5 in 2023 (APC: -2.6%, p < 0.01). Women exhibited higher AAMRs than men (15.9 versus 12.6), although men experienced a steeper decline (AAPC: -2.7%). Non-Hispanic (NH) Blacks reported the highest AAMR at 16.9, while NH Whites demonstrated the most considerable decline (AAPC: -2.7%, p < 0.01). AAMRs varied considerably, ranging from 27 in Mississippi to 6 in New York, with the Northeast region reflecting the most significant decline (AAPC: -3.5%). Furthermore, rural areas displayed higher AAMRs than urban regions (19.4 versus 14.3), although both populations exhibited declining trends.ConclusionsStroke mortality in AD patients has decreased but remains unevenly distributed, especially among women, NH Black individuals, rural communities, and Western U.S. residents. Targeted interventions are essential.

衰老、阿尔茨海默病和中风:美国25年死亡率趋势的纵向分析。
阿尔茨海默病(AD)和中风都是与年龄有关的疾病,它们具有共同的危险因素,如高血压、吸烟、糖尿病和APOE ε4基因型,这些因素在老年人中经常共存。目的:本研究根据性别、种族/民族和地理区域调查AD患者卒中相关死亡率的差异。方法采用AD (G30)和卒中(I60-I61、I63-I64、I69)的ICD编码,从CDC WONDER数据库中获取65岁及以上成年人每10万人的年龄调整死亡率(AAMRs)。联合点回归估计了年变化百分比(APC)和平均年变化百分比(AAPC), p
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来源期刊
Journal of Alzheimer's Disease
Journal of Alzheimer's Disease 医学-神经科学
CiteScore
6.40
自引率
7.50%
发文量
1327
审稿时长
2 months
期刊介绍: The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.
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