T2-Weighted Imaging and Intravoxel Incoherent Motion for Monitoring Glomerulonephritis.

IF 3.5 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Jian Liu, Yu Wu, Daoyu Yang, Xunlan Zhang, Rui Lv, Rongpin Wang, Xianchun Zeng
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引用次数: 0

Abstract

Background: Lack of reliable noninvasive diagnostic tools limits timely management of glomerulonephritis (GN), a major cause of chronic kidney disease.

Purpose: To validate the performance of intravoxel incoherent motion (IVIM) imaging and T2-weighted imaging (T2WI) in monitoring renal injury in rats with GN.

Study type: Prospective, animal model.

Subjects: Eighty-one Sprague-Dawley rats (54 GN, 27 control) underwent renal MRI at nine time points from Day 2 to Week 16 (GN: n = 6; control: n = 3 per time point).

Field strength/sequence: 3.0T; IVIM and T2WI.

Assessment: IVIM parameters (D, D*, f) and standardized signal intensities (SSI) on T2WI were calculated for renal cortex and outer medulla and correlated with histology.

Statistical tests: One-way analysis of variance was used for longitudinal changes and independent t-test for comparing GN and controls at each time point. Receiver operating characteristic (ROC) curve analysis assessed diagnostic performance for identifying GN.

Results: Cortex, outer stripe of outer medulla (OM) and inner stripe of the outer medulla (IM) showed early SSI increase followed by gradual decline. SSI of OM was significantly higher than controls at Days 5 (2.19 ± 0.76), 10 (2.99 ± 0.34), 15 (2.46 ± 0.37), and Week 4 (2.23 ± 0.66). In GN rats, D progressively declined from Day 2 to Week 16: from 1.51 ± 0.40 to 0.91 ± 0.45 (×10-3 mm2/s) in cortex, and from 1.37 ± 0.23 to 0.62 ± 0.19 (×10-3 mm2/s) in outer medulla. D* and f also decreased progressively in cortex and outer medulla. Significant inverse relationships were observed between IVIM parameters and serum biomarkers (r = -0.39 to -0.80). For diagnostic performance to identify GN, D achieved the highest area under the ROC curves in the cortex (0.926, 95% CI: 0.883-0.970) and outer medulla (0.975, 95% CI: 0.953-0.997).

Data conclusion: T2WI reveals early signal changes in GN. IVIM parameters track disease progression, correlate with serum biomarkers, and distinguish GN from healthy controls.

Level of evidence: 2:

Technical efficacy: Stage 1.

t2加权成像和体内非相干运动监测肾小球肾炎。
背景:缺乏可靠的无创诊断工具限制了肾小球肾炎(GN)的及时治疗,肾小球肾炎是慢性肾脏疾病的主要原因。目的:验证体内非相干运动成像(IVIM)和t2加权成像(T2WI)对肾脏病变大鼠肾损伤的监测作用。研究类型:前瞻性动物模型。实验对象:81只Sprague-Dawley大鼠(54只GN, 27只对照组)在第2天至第16周的9个时间点接受肾脏MRI检查(GN: n = 6,对照组:n = 3)。场强/序列:3.0T;IVIM和T2WI。评估:计算肾皮质、外髓质IVIM参数(D、D*、f)及T2WI标准化信号强度(SSI),并与组织学相关。统计检验:纵向变化采用单因素方差分析,各时间点GN与对照比较采用独立t检验。受试者工作特征(ROC)曲线分析评估GN的诊断效果。结果:皮层、外髓质外条纹(OM)和外髓质内条纹(IM)早期SSI升高,随后逐渐下降。OM组的SSI在第5天(2.19±0.76)、第10天(2.99±0.34)、第15天(2.46±0.37)和第4周(2.23±0.66)显著高于对照组。在GN大鼠中,D从第2天到第16周逐渐下降:皮层从1.51±0.40 (×10-3 mm2/s)下降到0.91±0.45 (×10-3 mm2/s),外髓从1.37±0.23 (×10-3 mm2/s)下降到0.62±0.19 (×10-3 mm2/s)。皮层和外髓质的D*和f也逐渐降低。IVIM参数与血清生物标志物呈显著负相关(r = -0.39 ~ -0.80)。对于鉴别GN的诊断性能,D在皮质(0.926,95% CI: 0.883-0.970)和外髓质(0.975,95% CI: 0.953-0.997)的ROC曲线下面积最高。数据结论:T2WI显示GN早期信号改变。IVIM参数跟踪疾病进展,与血清生物标志物相关,并将GN与健康对照区分开来。证据等级:2;技术功效:第1阶段。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
9.70
自引率
6.80%
发文量
494
审稿时长
2 months
期刊介绍: The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.
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