[¹⁸F]THK5351 uptake in multiple system atrophy compared with other parkinsonian disorders.

IF 4.6 2区医学 Q1 CLINICAL NEUROLOGY

Journal of Neurology Pub Date : 2025-09-24 DOI:10.1007/s00415-025-13389-2

Yoshihiko Horimoto, Emi Hayashi, Yoshihiro Ito, Nobuyuki Okamura, Noriyuki Matsukawa

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引用次数: 0

Abstract

Background: The pathological processes in the early stages of multiple system atrophy (MSA) are still incompletely understood. Moreover, early-stage MSA is difficult to diagnose.

Objectives: We investigated the monoamine oxidase-B positron emission tomography findings with an aim to characterize degeneration in the early stages of MSA.

Methods: Positron emission tomography using [¹⁸F]THK5351 was performed on three patients with relatively early stages of MSA: two with cerebellar-type MSA and one with parkinsonian-type MSA. The findings were compared with nine patients with other parkinsonian disorders (Lewy body disease, progressive supranuclear palsy, or spinocerebellar ataxia type 31) and six control subjects (Alzheimer disease or normal aging).

Results: Uptake of [¹⁸F]THK5351 in the middle cerebellar peduncles was distinctly higher in all three patients with MSA than in patients with other parkinsonian disorders or control subjects (both p < 0.001; unpaired t-tests).

Conclusions: The results of the presented patients suggest the potential diagnostic utility of [¹⁸F]THK5351 imaging and may help to clarify the preclinical pathology of the middle cerebellar peduncle in MSA.

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[18F]THK5351在帕金森病多系统萎缩中的摄取比较。

背景：多系统萎缩（MSA）早期的病理过程尚不完全清楚。此外，早期MSA很难诊断。目的：我们研究单胺氧化酶- b正电子发射断层扫描的表现，目的是表征早期MSA的变性。方法：采用[18F]THK5351对3例早期MSA患者进行正电子发射断层扫描，其中2例为小脑型MSA， 1例为帕金森型MSA。研究结果与9名其他帕金森病患者（路易体病、进行性核上性麻痹或脊髓小脑共济失调31型）和6名对照组（阿尔茨海默病或正常衰老）进行了比较。结果：三名MSA患者的[18F]THK5351在小脑中部脚的摄取明显高于其他帕金森病患者或对照组（均为p）。结论：本文患者的结果表明[18F]THK5351成像的潜在诊断价值，并可能有助于阐明MSA小脑中部脚的临床前病理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neurology 医学-临床神经学

CiteScore

10.00

自引率

5.00%

发文量

558

审稿时长

1 months

期刊介绍： The Journal of Neurology is an international peer-reviewed journal which provides a source for publishing original communications and reviews on clinical neurology covering the whole field. In addition, Letters to the Editors serve as a forum for clinical cases and the exchange of ideas which highlight important new findings. A section on Neurological progress serves to summarise the major findings in certain fields of neurology. Commentaries on new developments in clinical neuroscience, which may be commissioned or submitted, are published as editorials. Every neurologist interested in the current diagnosis and treatment of neurological disorders needs access to the information contained in this valuable journal.