Resveratrol potentiates the antibiofilm and antibacterial activity of polymyxin B against carbapenem-resistant Acinetobacter baumannii.

IF 3.2 3区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of Applied Microbiology Pub Date : 2025-10-06 DOI:10.1093/jambio/lxaf240

Yanhong Li, Bin Wu, Yanli Li, Yanwu Hu, Meijun Wang, Rongxin Liang

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引用次数: 0

Abstract

Aims: Polymyxins are generally recommended to be used in combination with other antibiotics for improving their antibacterial effects. As for treating carbapenem-resistant Acinetobacter baumannii infections, which antibiotic is the best option for polymyxin B-based combination therapy is still under debate. Resveratrol, a natural compound that can be well-tolerated by the human body, may have potential value in the polymyxin B-based combination therapy against carbapenem-resistant A. baumannii infections.

Methods and results: With checkerboard assays and time-killing studies, we have found that resveratrol increased the sensitivity of carbapenem-resistant A. baumannii to polymyxin B and enhanced the bactericidal activity of polymyxin B against carbapenem-resistant A. baumannii. With biofilm formation studies, we have confirmed that resveratrol potentiated the antibiofilm activity of polymyxin B and improved its bactericidal activity against the bacterial cells with established biofilms.

Conclusions: Resveratrol potentiates the antibiofilm and antibacterial activity of polymyxin B against carbapenem-resistant A. baumannii. Polymyxin B used in combination with resveratrol may have better clinical efficacy than polymyxin B monotherapy in the treatment of carbapenem-resistant A. baumannii infections.

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白藜芦醇增强了多粘菌素B对耐碳青霉烯鲍曼不动杆菌的抗菌活性。

目的：多粘菌素一般建议与其他抗生素合用，以提高其抗菌效果。对于耐碳青霉烯鲍曼不动杆菌感染的治疗，以多粘菌素b为基础的联合治疗哪种抗生素是最佳选择仍存在争议。白藜芦醇是一种人体耐受性良好的天然化合物，在以多粘菌素b为基础的联合治疗耐碳青霉烯鲍曼杆菌感染方面可能具有潜在价值。方法与结果：通过棋盘法和时间杀伤实验，我们发现白藜芦醇增加了耐碳青霉烯鲍曼不动杆菌对多粘菌素B的敏感性，增强了多粘菌素B对耐碳青霉烯鲍曼不动杆菌的杀菌活性。通过生物膜的形成研究，我们证实了白藜芦醇增强了多粘菌素B的抗生物膜活性，并提高了其对已形成生物膜的细菌细胞的杀菌活性。结论：白藜芦醇可增强多粘菌素B对耐碳青霉烯鲍曼不动杆菌的抗菌活性。多粘菌素B联合白藜芦醇治疗耐碳青霉烯类鲍曼杆菌感染的临床疗效可能优于多粘菌素B单药治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Applied Microbiology 生物-生物工程与应用微生物

CiteScore

7.30

自引率

2.50%

发文量

427

审稿时长

2.7 months

期刊介绍： Journal of & Letters in Applied Microbiology are two of the flagship research journals of the Society for Applied Microbiology (SfAM). For more than 75 years they have been publishing top quality research and reviews in the broad field of applied microbiology. The journals are provided to all SfAM members as well as having a global online readership totalling more than 500,000 downloads per year in more than 200 countries. Submitting authors can expect fast decision and publication times, averaging 33 days to first decision and 34 days from acceptance to online publication. There are no page charges.