A preliminary analysis of the relationship between follicle-stimulating hormone and metabolic parameters in postmenopausal women.

IF 1.7 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Gynecological Endocrinology Pub Date : 2025-12-31 Epub Date: 2025-09-24 DOI:10.1080/09513590.2025.2562195
Federica Barbagallo, Agata Cavallaro, Rossella Cannarella, Andrea Crafa, Rosita A Condorelli, Sandro La Vignera, Laura Cucinella, Rossella E Nappi, Aldo E Calogero
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Abstract

After menopause, women have a higher risk of developing metabolic disorders. The discovery of follicle-stimulating hormone (FSH) receptors in extra-ovarian tissues such as the adipose tissue suggests that FSH might influence metabolic processes in postmenopausal women. However, its role remains unclear. To examine the association between serum FSH levels and glucose and lipid metabolism in postmenopausal women. A retrospective analysis was conducted on 82 postmenopausal women (mean age 65.2 ± 8.1 years). Serum levels of FSH, 17β-estradiol (E2), glucose, insulin, HbA1c, total cholesterol, LDL, HDL, and triglycerides were measured. Insulin resistance was calculated using the HOMA-IR index. FSH levels did not significantly differ between women with and without dyslipidemia. However, FSH levels were significantly lower in women with type 2 diabetes (44.3 ± 13.8 IU/mL) compared to those with insulin resistance (60.6 ± 29.4 IU/mL) or normal glucose metabolism (69.4 ± 27.2 IU/mL; p = 0.045). Women in the lowest FSH quartile had higher glucose, insulin, and HOMA-IR values. A significant inverse correlation between FSH and insulin (r = -0.30, p = 0.03) was found, stronger in women more than six years postmenopausal. Serum FSH levels inversely correlate with glucose metabolism disorders in postmenopausal women. These findings suggest a possible role of FSH in glucose metabolism, deserving further study starting from the menopausal transition.

绝经后妇女促卵泡激素与代谢参数关系的初步分析。
绝经后,女性患代谢紊乱的风险更高。卵巢外组织(如脂肪组织)中卵泡刺激素(FSH)受体的发现表明,FSH可能影响绝经后妇女的代谢过程。然而,它的作用仍不清楚。研究绝经后妇女血清促卵泡刺激素水平与糖脂代谢的关系。回顾性分析82例绝经后妇女(平均年龄65.2±8.1岁)。测定血清FSH、17β-雌二醇(E2)、葡萄糖、胰岛素、HbA1c、总胆固醇、LDL、HDL和甘油三酯水平。使用HOMA-IR指数计算胰岛素抵抗。FSH水平在有和没有血脂异常的女性之间没有显著差异。然而,与胰岛素抵抗(60.6±29.4 IU/mL)或糖代谢正常(69.4±27.2 IU/mL; p = 0.045)的女性相比,2型糖尿病女性的FSH水平(44.3±13.8 IU/mL)显著降低。FSH最低的女性有较高的葡萄糖、胰岛素和HOMA-IR值。FSH和胰岛素之间存在显著的负相关(r = -0.30, p = 0.03),在绝经6年以上的女性中更为明显。绝经后妇女血清FSH水平与糖代谢紊乱呈负相关。这些发现提示卵泡刺激素在葡萄糖代谢中的可能作用,值得从更年期过渡开始进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Gynecological Endocrinology
Gynecological Endocrinology 医学-妇产科学
CiteScore
4.40
自引率
5.00%
发文量
137
审稿时长
3-6 weeks
期刊介绍: Gynecological Endocrinology , the official journal of the International Society of Gynecological Endocrinology, covers all the experimental, clinical and therapeutic aspects of this ever more important discipline. It includes, amongst others, papers relating to the control and function of the different endocrine glands in females, the effects of reproductive events on the endocrine system, and the consequences of endocrine disorders on reproduction
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