The Influence of Characteristics and Indexes (NLR, PNI, and SII) Evaluated at Admission on the Mortality Prediction of Infectious Endocarditis Patients.

IF 2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
International Journal of General Medicine Pub Date : 2025-09-18 eCollection Date: 2025-01-01 DOI:10.2147/IJGM.S535813
Aysegul Inci Sezen, Yusuf Emre Ozdemir, Deniz Borcak, Busra Nur Goklu, Zeynep Bilgin, Gulsum Turkyilmaz, Fatma Nihan Turhan Caglar, Habip Gedik, Kadriye Kart Yasar
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引用次数: 0

Abstract

Background: Infective endocarditis (IE) is a serious and potentially life-threatening infection with high morbidity and mortality. Early risk identification is critical for enabling timely treatment and preventing adverse outcomes. Recently, several low-cost and accessible inflammatory markers, such as the neutrophil-to-lymphocyte ratio (NLR), prognostic nutritional index (PNI), and systemic immune-inflammation index (SII), have gained attention for their potential prognostic value in infectious diseases.

Methods: This retrospective study evaluated patients diagnosed with definite IE between May 2014 and May 2024 at Bakırköy Dr. Sadi Konuk Training and Research Hospital. Clinical characteristics, laboratory parameters, complications, and outcomes were compared between survivors and non-survivors. The predictive value of NLR, PNI, and SII for in-hospital mortality was assessed.

Results: A total of 78 patients with IE were included, with an overall mortality rate of 52.5%. Non-survivors were significantly older (p = 0.001) and had higher rates of cardiac complications (p < 0.05). PNI values were significantly lower in non-survivors (p = 0.014). Undergoing cardiac surgery was associated with a lower mortality rate (p = 0.024).

Conclusion: PNI, a simple, inexpensive, and readily available marker, may provide valuable prognostic information in patients with infective endocarditis. This index could help in early risk stratification and clinical decision.

入院时评估的特征及指标(NLR、PNI、SII)对感染性心内膜炎患者死亡率预测的影响
背景:感染性心内膜炎(IE)是一种严重且可能危及生命的感染,具有很高的发病率和死亡率。早期风险识别对于及时治疗和预防不良后果至关重要。最近,一些低成本和可获得的炎症标志物,如中性粒细胞与淋巴细胞比率(NLR)、预后营养指数(PNI)和全身免疫炎症指数(SII),因其在传染病中的潜在预后价值而受到关注。方法:本回顾性研究评估了2014年5月至2024年5月期间在Bakırköy Dr. Sadi Konuk培训和研究医院诊断为明确IE的患者。比较幸存者和非幸存者的临床特征、实验室参数、并发症和结局。评估NLR、PNI和SII对院内死亡率的预测价值。结果:共纳入78例IE患者,总死亡率为52.5%。非幸存者明显年龄较大(p = 0.001),心脏并发症发生率较高(p < 0.05)。非幸存者的PNI值显著降低(p = 0.014)。接受心脏手术与较低的死亡率相关(p = 0.024)。结论:PNI是一种简单、廉价、易得的标志物,可为感染性心内膜炎患者提供有价值的预后信息。该指标有助于早期风险分层和临床决策。
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来源期刊
International Journal of General Medicine
International Journal of General Medicine Medicine-General Medicine
自引率
0.00%
发文量
1113
审稿时长
16 weeks
期刊介绍: The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.
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