The Influence of Characteristics and Indexes (NLR, PNI, and SII) Evaluated at Admission on the Mortality Prediction of Infectious Endocarditis Patients.
Aysegul Inci Sezen, Yusuf Emre Ozdemir, Deniz Borcak, Busra Nur Goklu, Zeynep Bilgin, Gulsum Turkyilmaz, Fatma Nihan Turhan Caglar, Habip Gedik, Kadriye Kart Yasar
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引用次数: 0
Abstract
Background: Infective endocarditis (IE) is a serious and potentially life-threatening infection with high morbidity and mortality. Early risk identification is critical for enabling timely treatment and preventing adverse outcomes. Recently, several low-cost and accessible inflammatory markers, such as the neutrophil-to-lymphocyte ratio (NLR), prognostic nutritional index (PNI), and systemic immune-inflammation index (SII), have gained attention for their potential prognostic value in infectious diseases.
Methods: This retrospective study evaluated patients diagnosed with definite IE between May 2014 and May 2024 at Bakırköy Dr. Sadi Konuk Training and Research Hospital. Clinical characteristics, laboratory parameters, complications, and outcomes were compared between survivors and non-survivors. The predictive value of NLR, PNI, and SII for in-hospital mortality was assessed.
Results: A total of 78 patients with IE were included, with an overall mortality rate of 52.5%. Non-survivors were significantly older (p = 0.001) and had higher rates of cardiac complications (p < 0.05). PNI values were significantly lower in non-survivors (p = 0.014). Undergoing cardiac surgery was associated with a lower mortality rate (p = 0.024).
Conclusion: PNI, a simple, inexpensive, and readily available marker, may provide valuable prognostic information in patients with infective endocarditis. This index could help in early risk stratification and clinical decision.
期刊介绍:
The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas.
A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal.
As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.