Resveratrol: potential therapeutic effects on ocular health.

IF 5.3 2区医学 Q2 IMMUNOLOGY

Inflammopharmacology Pub Date : 2025-09-23 DOI:10.1007/s10787-025-01947-z

Bennett Kurien Biju, Marina Andavar

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Abstract

Resveratrol, a polyphenolic compound predominantly found in grapes and red wine, exhibits significant biological activity due to its potent antioxidant and anti-inflammatory properties. Known for its cardioprotective, chemotherapeutic, neuroprotective, and anti-aging effects, resveratrol has garnered attention for its potential in managing age-related ocular diseases, such as glaucoma, cataract, diabetic retinopathy, and macular degeneration-conditions, where oxidative stress and inflammation play central roles in disease progression and vision impairment. Both in vitro and animal studies indicate that resveratrol impacts key biological pathways, including oxidative stress modulation, inflammation reduction, mitochondrial protection, apoptosis regulation, and angiogenesis suppression, which are implicated in the pathology of these ocular conditions. Resveratrol with antioxidant, anti-inflammatory, and anti-angiogenic properties, shows promise in treating ophthalmic diseases by targeting oxidative stress and abnormal angiogenesis, offering a safer, non-invasive alternative to conventional drugs and better scientific validation than herbal remedies. This review synthesizes current research on resveratrol's mechanisms of action, therapeutic potential, and limitations as a treatment for eye disorders, highlighting its promise as a nutritional intervention and areas requiring further exploration.

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白藜芦醇：对眼部健康的潜在治疗作用。

白藜芦醇是一种多酚类化合物，主要存在于葡萄和红酒中，由于其有效的抗氧化和抗炎特性，它表现出显著的生物活性。白藜芦醇以其心脏保护、化学治疗、神经保护和抗衰老作用而闻名，其在治疗与年龄相关的眼部疾病（如青光眼、白内障、糖尿病性视网膜病变和黄斑变性）方面的潜力引起了人们的关注，其中氧化应激和炎症在疾病进展和视力损害中起着核心作用。体外和动物实验均表明，白藜芦醇影响关键的生物通路，包括氧化应激调节、炎症减少、线粒体保护、细胞凋亡调节和血管生成抑制，这些通路与这些眼部疾病的病理有关。白藜芦醇具有抗氧化、抗炎和抗血管生成的特性，通过靶向氧化应激和异常血管生成来治疗眼科疾病，提供了一种比传统药物更安全、非侵入性的替代方案，并且比草药疗法得到了更好的科学验证。本文综述了目前关于白藜芦醇治疗眼部疾病的作用机制、治疗潜力和局限性的研究，强调了白藜芦醇作为营养干预的前景和需要进一步探索的领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Inflammopharmacology IMMUNOLOGYTOXICOLOGY-TOXICOLOGY

CiteScore

8.00

自引率

3.40%

发文量

200

期刊介绍： Inflammopharmacology is the official publication of the Gastrointestinal Section of the International Union of Basic and Clinical Pharmacology (IUPHAR) and the Hungarian Experimental and Clinical Pharmacology Society (HECPS). Inflammopharmacology publishes papers on all aspects of inflammation and its pharmacological control emphasizing comparisons of (a) different inflammatory states, and (b) the actions, therapeutic efficacy and safety of drugs employed in the treatment of inflammatory conditions. The comparative aspects of the types of inflammatory conditions include gastrointestinal disease (e.g. ulcerative colitis, Crohn''s disease), parasitic diseases, toxicological manifestations of the effects of drugs and environmental agents, arthritic conditions, and inflammatory effects of injury or aging on skeletal muscle. The journal has seven main interest areas: -Drug-Disease Interactions - Conditional Pharmacology - i.e. where the condition (disease or stress state) influences the therapeutic response and side (adverse) effects from anti-inflammatory drugs. Mechanisms of drug-disease and drug disease interactions and the role of different stress states -Rheumatology - particular emphasis on methods of measurement of clinical response effects of new agents, adverse effects from anti-rheumatic drugs -Gastroenterology - with particular emphasis on animal and human models, mechanisms of mucosal inflammation and ulceration and effects of novel and established anti-ulcer, anti-inflammatory agents, or antiparasitic agents -Neuro-Inflammation and Pain - model systems, pharmacology of new analgesic agents and mechanisms of neuro-inflammation and pain -Novel drugs, natural products and nutraceuticals - and their effects on inflammatory processes, especially where there are indications of novel modes action compared with conventional drugs e.g. NSAIDs -Muscle-immune interactions during inflammation [...]