{"title":"Jasmine sambac L. essential oil attenuates inflammation and pain via TRPV1.","authors":"Sahar Jaffal, Aluck Thipayarat, Samer Alqaraleh, Jakrapop Wongwiwat, Pattarin Supanivatin","doi":"10.1007/s10787-025-01929-1","DOIUrl":null,"url":null,"abstract":"<p><p>Pain and inflammation are complex physiological responses. The drugs that are available in the market have multiple side effects. Thus, the search for safer effective therapeutics became a significant area of research. In this study, Jasmine sambac L. essential oil, which is aromatic and therapeutic in nature, has been studied for its potential anti-inflammatory and anti-nociceptive activities as well as its mechanism of action. The findings from this research indicated that the intraplantar (ipl) administration of jasmine essential oil to the animals produced anti-inflammatory effects in the carrageenan-induced paw edema model. In addition, jasmine essential oil showed significant inhibition of pain responses compared to the control group in the acetic acid-induced writhing test and immersion tail-flick test. These findings suggest that jasmine oil exhibits anti-nociceptive and anti-inflammatory effects in animals. More data are needed to determine its therapeutic value in human clinical trials. The anti-inflammatory and anti-nociceptive effects were mediated by the transient receptor potential vanilloid 1 (TRPV1), a key pain receptor. The chemical composition of jasmine essential oil was analyzed by gas chromatography-mass spectrometry (GC-MS) to determine the bioactive constituents that can be responsible for these effects. The results showed that the oil consists of active constituents with various therapeutic activities as reported in earlier studies. Thus, jasmine essential oil can be utilized as a complementary therapy for pain and inflammation treatment.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":5.3000,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Inflammopharmacology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10787-025-01929-1","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Pain and inflammation are complex physiological responses. The drugs that are available in the market have multiple side effects. Thus, the search for safer effective therapeutics became a significant area of research. In this study, Jasmine sambac L. essential oil, which is aromatic and therapeutic in nature, has been studied for its potential anti-inflammatory and anti-nociceptive activities as well as its mechanism of action. The findings from this research indicated that the intraplantar (ipl) administration of jasmine essential oil to the animals produced anti-inflammatory effects in the carrageenan-induced paw edema model. In addition, jasmine essential oil showed significant inhibition of pain responses compared to the control group in the acetic acid-induced writhing test and immersion tail-flick test. These findings suggest that jasmine oil exhibits anti-nociceptive and anti-inflammatory effects in animals. More data are needed to determine its therapeutic value in human clinical trials. The anti-inflammatory and anti-nociceptive effects were mediated by the transient receptor potential vanilloid 1 (TRPV1), a key pain receptor. The chemical composition of jasmine essential oil was analyzed by gas chromatography-mass spectrometry (GC-MS) to determine the bioactive constituents that can be responsible for these effects. The results showed that the oil consists of active constituents with various therapeutic activities as reported in earlier studies. Thus, jasmine essential oil can be utilized as a complementary therapy for pain and inflammation treatment.
期刊介绍：
Inflammopharmacology is the official publication of the Gastrointestinal Section of the International Union of Basic and Clinical Pharmacology (IUPHAR) and the Hungarian Experimental and Clinical Pharmacology Society (HECPS). Inflammopharmacology publishes papers on all aspects of inflammation and its pharmacological control emphasizing comparisons of (a) different inflammatory states, and (b) the actions, therapeutic efficacy and safety of drugs employed in the treatment of inflammatory conditions. The comparative aspects of the types of inflammatory conditions include gastrointestinal disease (e.g. ulcerative colitis, Crohn''s disease), parasitic diseases, toxicological manifestations of the effects of drugs and environmental agents, arthritic conditions, and inflammatory effects of injury or aging on skeletal muscle. The journal has seven main interest areas:
-Drug-Disease Interactions - Conditional Pharmacology - i.e. where the condition (disease or stress state) influences the therapeutic response and side (adverse) effects from anti-inflammatory drugs. Mechanisms of drug-disease and drug disease interactions and the role of different stress states
-Rheumatology - particular emphasis on methods of measurement of clinical response effects of new agents, adverse effects from anti-rheumatic drugs
-Gastroenterology - with particular emphasis on animal and human models, mechanisms of mucosal inflammation and ulceration and effects of novel and established anti-ulcer, anti-inflammatory agents, or antiparasitic agents
-Neuro-Inflammation and Pain - model systems, pharmacology of new analgesic agents and mechanisms of neuro-inflammation and pain
-Novel drugs, natural products and nutraceuticals - and their effects on inflammatory processes, especially where there are indications of novel modes action compared with conventional drugs e.g. NSAIDs
-Muscle-immune interactions during inflammation [...]
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