Microbiome-based approaches to personalized nutrition: from gut health to disease prevention.

IF 3.1 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Parveen Nisa, Arivarasan Vishnu Kirthi, Priyobrata Sinha
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引用次数: 0

Abstract

A complex community of trillions of microorganisms, the human gut microbiome has become a major regulator of health, impacting immune system function, metabolism, digestion, and even brain activity. Recent findings demonstrate how the microbiota is significantly shaped by diet and how the microbiome in turn influences how each person reacts to nutrition. In order to promote disease prevention and long-term health outcomes, this review examines how microbiome-driven approaches are transforming personalized nutrition by going beyond traditional dietary models. The review addresses how dietary elements like fibre, polyphenols, prebiotics, and fermented foods support metabolic activity and microbial diversity. It also discusses the connections between microbial imbalances, or dysbiosis, and illnesses like diabetes, obesity, heart disease, inflammatory bowel disease, and mental health issues. Personalized dietary recommendations based on individual microbiome profiles are becoming more and more possible with the development of high-throughput sequencing, machine learning, and multi-omics tools. Aside from addressing ethical concerns like data protection, affordability, and fair access to individualized interventions, the review also emphasizes the creation of customized probiotics and synbiotics that are made to fit the unique microbiome profiles of each individual. In the end, this review emphasizes how crucial it is to incorporate microbiome science into customized nutrition in order to support preventive healthcare and enhance clinical results.

基于微生物组的个性化营养方法:从肠道健康到疾病预防。
作为一个由数万亿微生物组成的复杂群落,人类肠道微生物组已经成为健康的主要调节器,影响免疫系统功能、代谢、消化,甚至大脑活动。最近的研究结果表明,饮食如何显著地塑造微生物群,以及微生物群如何反过来影响每个人对营养的反应。为了促进疾病预防和长期健康结果,本综述探讨了微生物组驱动的方法如何通过超越传统的饮食模式来改变个性化营养。这篇综述阐述了膳食元素如纤维、多酚、益生元和发酵食品如何支持代谢活动和微生物多样性。它还讨论了微生物失衡或生态失调与糖尿病、肥胖、心脏病、炎症性肠病和精神健康问题等疾病之间的联系。随着高通量测序、机器学习和多组学工具的发展,基于个体微生物组谱的个性化饮食推荐变得越来越可能。除了解决数据保护、可负担性和公平获得个性化干预等伦理问题外,该综述还强调了定制益生菌和合成菌的创造,以适应每个人独特的微生物群特征。最后,本综述强调了将微生物组科学纳入定制营养以支持预防性保健和提高临床结果的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Folia microbiologica
Folia microbiologica 工程技术-生物工程与应用微生物
CiteScore
5.80
自引率
0.00%
发文量
82
审稿时长
6-12 weeks
期刊介绍: Unlike journals which specialize ever more narrowly, Folia Microbiologica (FM) takes an open approach that spans general, soil, medical and industrial microbiology, plus some branches of immunology. This English-language journal publishes original papers, reviews and mini-reviews, short communications and book reviews. The coverage includes cutting-edge methods and promising new topics, as well as studies using established methods that exhibit promise in practical applications such as medicine, animal husbandry and more. The coverage of FM is expanding beyond Central and Eastern Europe, with a growing proportion of its contents contributed by international authors.
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