{"title":"Microbiome-based approaches to personalized nutrition: from gut health to disease prevention.","authors":"Parveen Nisa, Arivarasan Vishnu Kirthi, Priyobrata Sinha","doi":"10.1007/s12223-025-01337-6","DOIUrl":null,"url":null,"abstract":"<p><p>A complex community of trillions of microorganisms, the human gut microbiome has become a major regulator of health, impacting immune system function, metabolism, digestion, and even brain activity. Recent findings demonstrate how the microbiota is significantly shaped by diet and how the microbiome in turn influences how each person reacts to nutrition. In order to promote disease prevention and long-term health outcomes, this review examines how microbiome-driven approaches are transforming personalized nutrition by going beyond traditional dietary models. The review addresses how dietary elements like fibre, polyphenols, prebiotics, and fermented foods support metabolic activity and microbial diversity. It also discusses the connections between microbial imbalances, or dysbiosis, and illnesses like diabetes, obesity, heart disease, inflammatory bowel disease, and mental health issues. Personalized dietary recommendations based on individual microbiome profiles are becoming more and more possible with the development of high-throughput sequencing, machine learning, and multi-omics tools. Aside from addressing ethical concerns like data protection, affordability, and fair access to individualized interventions, the review also emphasizes the creation of customized probiotics and synbiotics that are made to fit the unique microbiome profiles of each individual. In the end, this review emphasizes how crucial it is to incorporate microbiome science into customized nutrition in order to support preventive healthcare and enhance clinical results.</p>","PeriodicalId":12346,"journal":{"name":"Folia microbiologica","volume":" ","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Folia microbiologica","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s12223-025-01337-6","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
A complex community of trillions of microorganisms, the human gut microbiome has become a major regulator of health, impacting immune system function, metabolism, digestion, and even brain activity. Recent findings demonstrate how the microbiota is significantly shaped by diet and how the microbiome in turn influences how each person reacts to nutrition. In order to promote disease prevention and long-term health outcomes, this review examines how microbiome-driven approaches are transforming personalized nutrition by going beyond traditional dietary models. The review addresses how dietary elements like fibre, polyphenols, prebiotics, and fermented foods support metabolic activity and microbial diversity. It also discusses the connections between microbial imbalances, or dysbiosis, and illnesses like diabetes, obesity, heart disease, inflammatory bowel disease, and mental health issues. Personalized dietary recommendations based on individual microbiome profiles are becoming more and more possible with the development of high-throughput sequencing, machine learning, and multi-omics tools. Aside from addressing ethical concerns like data protection, affordability, and fair access to individualized interventions, the review also emphasizes the creation of customized probiotics and synbiotics that are made to fit the unique microbiome profiles of each individual. In the end, this review emphasizes how crucial it is to incorporate microbiome science into customized nutrition in order to support preventive healthcare and enhance clinical results.
期刊介绍:
Unlike journals which specialize ever more narrowly, Folia Microbiologica (FM) takes an open approach that spans general, soil, medical and industrial microbiology, plus some branches of immunology. This English-language journal publishes original papers, reviews and mini-reviews, short communications and book reviews. The coverage includes cutting-edge methods and promising new topics, as well as studies using established methods that exhibit promise in practical applications such as medicine, animal husbandry and more. The coverage of FM is expanding beyond Central and Eastern Europe, with a growing proportion of its contents contributed by international authors.