Microfluidic- and Field-Assisted 3D Printing: Leveraging Fluidic Control, Electrokinetic Phenomena, and Other Physical Fields to Advance Additive Manufacturing.

IF 2.5 3区生物学 Q2 BIOCHEMICAL RESEARCH METHODS

ELECTROPHORESIS Pub Date : 2025-09-23 DOI:10.1002/elps.70041

Guillermo Ramirez-Alvarado, Gongchen Sun

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引用次数: 0

Abstract

Three-dimensional (3D) printing has revolutionized manufacturing by enabling the rapid fabrication of complex structures, yet conventional 3D techniques remain constrained by inherent limitations in resolution, speed, and multi-material integration. To address these challenges, emerging approaches such as microfluidic-assisted and field-assisted additive manufacturing have been developed to enhance the capabilities and versatility of the method. Microfluidic-assisted 3D printing leverages controlled flow patterns for material deposition and control, material gradient formation, and advanced polymerization processes. Field-assisted methods, including electric-, acoustic-, and interface-assisted approaches, directly manipulate materials during printing to enable advanced functionalities and material properties. This review summarizes the latest advancements in microfluidic- and field-assisted 3D printing, highlighting their unique advantage in overcoming current 3D printing limitations and their potential to drive innovation in applications ranging from biomedical devices to functional materials development.

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微流体和场辅助3D打印：利用流体控制，电动现象和其他物理领域来推进增材制造。

三维（3D）打印通过实现复杂结构的快速制造而彻底改变了制造业，然而传统的3D技术仍然受到分辨率、速度和多材料集成的固有限制。为了应对这些挑战，诸如微流体辅助和现场辅助增材制造等新兴方法已经被开发出来，以增强该方法的能力和多功能性。微流体辅助3D打印利用受控的流动模式进行材料沉积和控制，材料梯度形成和先进的聚合过程。场辅助方法，包括电、声和界面辅助方法，在打印过程中直接操纵材料，以实现先进的功能和材料特性。本文总结了微流体和现场辅助3D打印的最新进展，强调了它们在克服当前3D打印限制方面的独特优势，以及它们在从生物医学设备到功能材料开发等应用领域推动创新的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ELECTROPHORESIS 生物-分析化学

CiteScore

6.30

自引率

13.80%

发文量

244

审稿时长

1.9 months

期刊介绍： ELECTROPHORESIS is an international journal that publishes original manuscripts on all aspects of electrophoresis, and liquid phase separations (e.g., HPLC, micro- and nano-LC, UHPLC, micro- and nano-fluidics, liquid-phase micro-extractions, etc.). Topics include new or improved analytical and preparative methods, sample preparation, development of theory, and innovative applications of electrophoretic and liquid phase separations methods in the study of nucleic acids, proteins, carbohydrates natural products, pharmaceuticals, food analysis, environmental species and other compounds of importance to the life sciences. Papers in the areas of microfluidics and proteomics, which are not limited to electrophoresis-based methods, will also be accepted for publication. Contributions focused on hyphenated and omics techniques are also of interest. Proteomics is within the scope, if related to its fundamentals and new technical approaches. Proteomics applications are only considered in particular cases. Papers describing the application of standard electrophoretic methods will not be considered. Papers on nanoanalysis intended for publication in ELECTROPHORESIS should focus on one or more of the following topics: • Nanoscale electrokinetics and phenomena related to electric double layer and/or confinement in nano-sized geometry • Single cell and subcellular analysis • Nanosensors and ultrasensitive detection aspects (e.g., involving quantum dots, "nanoelectrodes" or nanospray MS) • Nanoscale/nanopore DNA sequencing (next generation sequencing) • Micro- and nanoscale sample preparation • Nanoparticles and cells analyses by dielectrophoresis • Separation-based analysis using nanoparticles, nanotubes and nanowires.