The impact of three distinct probiotic supplements on the gut microbiota and its metabolites in healthy adults.

IF 3.1 4区医学 Q2 MICROBIOLOGY

Beneficial microbes Pub Date : 2025-09-05 DOI:10.1163/18762891-bja00096

D R Michael, D A John, N Coates, I Guschina, J A K McDonald, N P Danckert, M A Valdivia-Garcı́a, G Ramanathan, S F Plummer, D Wang, J R Marchesi, B H Mullish

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Abstract

The effects of probiotics on the gut microbiota and microbial metabolites in healthy individuals are not well understood. Faecal and serum samples were collected at the start and end of a 3-month, double-blind, placebo-controlled, randomised study with three different probiotic formulations in free-living, healthy adults. The composition of the faecal microbiota and levels of faecal and/or serum short-chain fatty acids (SCFA) and bile acids (BA) were measured and the probiotic formulations were found to impart differing effects including shifts in the composition and structure of the faecal microbiota, enhanced levels of circulating short chain fatty acids such as butyrate and propionate, and elevated levels of sulphated bile acids in faeces. This was in contrast to the outcomes for the placebo population where very little change occurred over the study. These findings demonstrate that probiotic supplementation elicits formulation specific effects and that there are potential benefits for healthy individuals.

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三种不同的益生菌补充剂对健康成人肠道微生物群及其代谢物的影响。

益生菌对健康个体肠道菌群和微生物代谢物的影响尚不清楚。在一项为期3个月、双盲、安慰剂对照的随机研究开始和结束时，收集了粪便和血清样本，研究对象是自由生活的健康成年人，使用三种不同的益生菌配方。测量了粪便微生物群的组成以及粪便和/或血清短链脂肪酸（SCFA）和胆汁酸（BA）的水平，发现益生菌制剂具有不同的效果，包括粪便微生物群的组成和结构的变化，循环短链脂肪酸（如丁酸盐和丙酸盐）水平的提高，以及粪便中硫酸胆汁酸水平的升高。这与安慰剂组的结果形成对比，安慰剂组的结果在整个研究过程中几乎没有变化。这些发现表明，益生菌补充剂可以产生配方特定的效果，并且对健康个体有潜在的益处。

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来源期刊

Beneficial microbes MICROBIOLOGY-NUTRITION & DIETETICS

CiteScore

7.90

自引率

1.90%

发文量

审稿时长

>12 weeks

期刊介绍： Beneficial Microbes is a peer-reviewed scientific journal with a specific area of focus: the promotion of the science of microbes beneficial to the health and wellbeing of man and animal. The journal contains original research papers and critical reviews in all areas dealing with beneficial microbes in both the small and large intestine, together with opinions, a calendar of forthcoming beneficial microbes-related events and book reviews. The journal takes a multidisciplinary approach and focuses on a broad spectrum of issues, including safety aspects of pro- & prebiotics, regulatory aspects, mechanisms of action, health benefits for the host, optimal production processes, screening methods, (meta)genomics, proteomics and metabolomics, host and bacterial physiology, application, and role in health and disease in man and animal. Beneficial Microbes is intended to serve the needs of researchers and professionals from the scientific community and industry, as well as those of policy makers and regulators. The journal will have five major sections: * Food, nutrition and health * Animal nutrition * Processing and application * Regulatory & safety aspects * Medical & health applications In these sections, topics dealt with by Beneficial Microbes include: * Worldwide safety and regulatory issues * Human and animal nutrition and health effects * Latest discoveries in mechanistic studies and screening methods to unravel mode of action * Host physiology related to allergy, inflammation, obesity, etc. * Trends in application of (meta)genomics, proteomics and metabolomics * New developments in how processing optimizes pro- & prebiotics for application * Bacterial physiology related to health benefits