Marcello Di Martino, Giorgio Ercolani, Federica Cipriani, Gianluca Baiocchi, Roberto Bordonaro, Matteo Cescon, Antonio Frena, Felice Giuliante, Gianluca Grazi, Salvatore Gruttadauria, Giovanni Marchegiani, Riccardo Memeo, Fabrizio Panaro, Fabrizio Romano, Andrea Ruzzenente, Marcello Spampinato, Guido Alberto Tiberio, Guido Torzilli, Roberto Troisi, Matteo Donadon
{"title":"Non-colorectal liver metastases undergoing liver resection: the NONCOLMET study group.","authors":"Marcello Di Martino, Giorgio Ercolani, Federica Cipriani, Gianluca Baiocchi, Roberto Bordonaro, Matteo Cescon, Antonio Frena, Felice Giuliante, Gianluca Grazi, Salvatore Gruttadauria, Giovanni Marchegiani, Riccardo Memeo, Fabrizio Panaro, Fabrizio Romano, Andrea Ruzzenente, Marcello Spampinato, Guido Alberto Tiberio, Guido Torzilli, Roberto Troisi, Matteo Donadon","doi":"10.1159/000548423","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>While the resection of colorectal liver metastases (CRLM) is a well-established procedure, with survival rates superior to chemotherapy alone, controversial data still exist on liver resection for non-colorectal liver metastases (NCRLM). These patients comprise a diverse and heterogeneous group usually excluded from surgery. To date, only few retrospective reports are available on the surgical treatment of NCRLM. The NONCOLMET study aims to build a comprehensive registry of patients undergoing liver resection for NCRLM, providing robust retrospective and prospective data to describe clinical practices, outcomes, and identify prognostic factors.</p><p><strong>Methods: </strong>The study consists of two phases: (1) retrospective collection of data from patients treated between 2010-2024 and (2) prospective enrolment from 2025. Patients aged ≥18 years with histologically confirmed NCRLM undergoing liver resection will be included. Data will be recorded via a standardized electronic case report form (eCRF) in the RedCap platform. The following endpoints will be evaluated: oncological outcomes including overall survival (OS), disease-free Survival (DFS) and disease relapse; post-operative mortality at 30 and 90 days with causes of death; post-procedural complications; predictor variables of short- and long-term outcomes. These outcomes will be used to elaborate a risk score models. The study protococol was registered on Clincaltrials.gov (NCT06542926).</p><p><strong>Conclusions: </strong>NONCOLMET will offer crucial insights into the surgical management of NCRLM, helping refine patient selection criteria and informing future clinical guidelines.</p>","PeriodicalId":11241,"journal":{"name":"Digestive Surgery","volume":" ","pages":"1-8"},"PeriodicalIF":1.2000,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Digestive Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000548423","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: While the resection of colorectal liver metastases (CRLM) is a well-established procedure, with survival rates superior to chemotherapy alone, controversial data still exist on liver resection for non-colorectal liver metastases (NCRLM). These patients comprise a diverse and heterogeneous group usually excluded from surgery. To date, only few retrospective reports are available on the surgical treatment of NCRLM. The NONCOLMET study aims to build a comprehensive registry of patients undergoing liver resection for NCRLM, providing robust retrospective and prospective data to describe clinical practices, outcomes, and identify prognostic factors.
Methods: The study consists of two phases: (1) retrospective collection of data from patients treated between 2010-2024 and (2) prospective enrolment from 2025. Patients aged ≥18 years with histologically confirmed NCRLM undergoing liver resection will be included. Data will be recorded via a standardized electronic case report form (eCRF) in the RedCap platform. The following endpoints will be evaluated: oncological outcomes including overall survival (OS), disease-free Survival (DFS) and disease relapse; post-operative mortality at 30 and 90 days with causes of death; post-procedural complications; predictor variables of short- and long-term outcomes. These outcomes will be used to elaborate a risk score models. The study protococol was registered on Clincaltrials.gov (NCT06542926).
Conclusions: NONCOLMET will offer crucial insights into the surgical management of NCRLM, helping refine patient selection criteria and informing future clinical guidelines.
期刊介绍:
''Digestive Surgery'' presents a comprehensive overview in the field of gastrointestinal surgery. Interdisciplinary in scope, the journal keeps the specialist aware of advances in all fields that contribute to improvements in the diagnosis and treatment of gastrointestinal disease. Particular emphasis is given to articles that evaluate not only recent clinical developments, especially clinical trials and technical innovations such as new endoscopic and laparoscopic procedures, but also relevant translational research. Each contribution is carefully aligned with the need of the digestive surgeon. Thus, the journal is an important component of the continuing medical education of surgeons who want their practice to benefit from a familiarity with new knowledge in all its dimensions.