Global, regional, and national burden of atrial fibrillation and flutter associated with metabolic risk factors, 1990-2021.

IF 2.8 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Frontiers in Cardiovascular Medicine Pub Date : 2025-09-08 eCollection Date: 2025-01-01 DOI:10.3389/fcvm.2025.1578908

Lu Wang, Xinghua Qin, Linyan Jin, Haoyu Gong, Chong Gao, Hongtao Wang, Peng Liu

{"title":"Global, regional, and national burden of atrial fibrillation and flutter associated with metabolic risk factors, 1990-2021.","authors":"Lu Wang, Xinghua Qin, Linyan Jin, Haoyu Gong, Chong Gao, Hongtao Wang, Peng Liu","doi":"10.3389/fcvm.2025.1578908","DOIUrl":null,"url":null,"abstract":"Objectives: Atrial fibrillation/flutter (AF/AFL) is increasingly correlated with metabolic risk factors. This study analyzed mortality, disability-adjusted life years (DALYs), annual percentage changes (APCs), and estimated annual percentage changes (EAPCs), stratified by age, sex, Socio-demographic Index (SDI), and region, to evaluate the global burden of AF/AFL linked to metabolic risk factors.Methods: Data on prevalence, incidence, mortality, DALYs, and age-standardized rates (ASRs) for AF/AFL associated with metabolic risk factors were extracted from the Global Burden of Disease (GBD) 2021 study. EAPCs were used to assess temporal trends in ASRs.Results: In 2021, metabolic risk factors were correlated with approximately 117,012 deaths and 2,881,800 DALYs globally due to AF/AFL, reflecting increases of 196.08% and 154.51%, respectively, compared to 1990. The burden varied considerably by sex, SDI, and region. Women, older adults, and high-SDI regions exhibited higher burdens, while men, younger individuals, and low-SDI regions showed more rapid increases.Conclusions: Metabolic risk factors are strongly correlated with the global burden of AF/AFL. Strengthening cost-effective interventions targeting these modifiable risks is essential-particularly in regions facing high or rapidly growing burdens.","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1578908"},"PeriodicalIF":2.8000,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12450952/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Cardiovascular Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fcvm.2025.1578908","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: Atrial fibrillation/flutter (AF/AFL) is increasingly correlated with metabolic risk factors. This study analyzed mortality, disability-adjusted life years (DALYs), annual percentage changes (APCs), and estimated annual percentage changes (EAPCs), stratified by age, sex, Socio-demographic Index (SDI), and region, to evaluate the global burden of AF/AFL linked to metabolic risk factors.

Methods: Data on prevalence, incidence, mortality, DALYs, and age-standardized rates (ASRs) for AF/AFL associated with metabolic risk factors were extracted from the Global Burden of Disease (GBD) 2021 study. EAPCs were used to assess temporal trends in ASRs.

Results: In 2021, metabolic risk factors were correlated with approximately 117,012 deaths and 2,881,800 DALYs globally due to AF/AFL, reflecting increases of 196.08% and 154.51%, respectively, compared to 1990. The burden varied considerably by sex, SDI, and region. Women, older adults, and high-SDI regions exhibited higher burdens, while men, younger individuals, and low-SDI regions showed more rapid increases.

Conclusions: Metabolic risk factors are strongly correlated with the global burden of AF/AFL. Strengthening cost-effective interventions targeting these modifiable risks is essential-particularly in regions facing high or rapidly growing burdens.

查看原文本刊更多论文

与代谢危险因素相关的全球、区域和国家心房颤动和扑动负担，1990-2021

目的：心房颤动/扑动（AF/AFL）越来越多地与代谢危险因素相关。本研究分析了死亡率、残疾调整生命年（DALYs）、年百分比变化（APCs）和估计年百分比变化（EAPCs），按年龄、性别、社会人口指数（SDI）和地区分层，以评估与代谢危险因素相关的AF/AFL的全球负担。方法：从全球疾病负担（GBD） 2021研究中提取与代谢危险因素相关的AF/AFL的患病率、发病率、死亡率、DALYs和年龄标准化率（ASRs）数据。EAPCs用于评估asr的时间趋势。结果：2021年，代谢危险因素与全球因AF/AFL导致的约117,012例死亡和2,881,800例DALYs相关，与1990年相比分别增加了196.08%和154.51%。这种负担因性别、SDI和地区而有很大差异。女性、老年人和高sdi地区表现出更高的负担，而男性、年轻人和低sdi地区表现出更快的增加。结论：代谢危险因素与AF/AFL的全球负担密切相关。加强针对这些可改变风险的具有成本效益的干预措施至关重要，特别是在面临高负担或快速增长的区域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Frontiers in Cardiovascular Medicine Medicine-Cardiology and Cardiovascular Medicine

CiteScore

3.80

自引率

11.10%

发文量

3529

审稿时长

14 weeks

期刊介绍： Frontiers? Which frontiers? Where exactly are the frontiers of cardiovascular medicine? And who should be defining these frontiers? At Frontiers in Cardiovascular Medicine we believe it is worth being curious to foresee and explore beyond the current frontiers. In other words, we would like, through the articles published by our community journal Frontiers in Cardiovascular Medicine, to anticipate the future of cardiovascular medicine, and thus better prevent cardiovascular disorders and improve therapeutic options and outcomes of our patients.