Physical Activity, Arterial Stiffness, and Risk of Cardiovascular Disease and Death in Men and Women: A Population-Based Study.

IF 2.2 3区 医学 Q2 PERIPHERAL VASCULAR DISEASE
Johannes Holm, Viktor Eriksson Lippe, Peter M Nilsson, Benjamin Nilsson Wadström
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Abstract

Physical activity lowers risk of cardiovascular disease and may also decrease arterial stiffness. We aimed to investigate whether arterial stiffness can explain part of the association between physical activity and the risk of major adverse cardiovascular events (MACE) and all-cause death in men and women. We followed 2583 individuals from the Malmö Diet and Cancer study (2007-2012) for occurrence of MACE in Swedish nationwide registries (mean follow-up: 9 years). Physical activity was self-assessed using a questionnaire. Arterial stiffness was assessed by carotid-femoral pulse wave velocity (cfPWV), the gold standard. Survival analyses were performed using Cox regression. In all individuals, multivariable adjusted hazard ratios per 1 m/s higher PWV were 1.09 (95% confidence interval: 1.05-1.14) for MACE and 1.06 (1.03-1.09) for death. Explained risk estimates for the association from physical activity through arterial stiffness were 12% (0%-100%) for risk of MACE and 5% (1%-16%) for risk of death; in men, corresponding results were 7% (0.4%-28%) and 7% (0%-51%). For women, physical activity was not associated with risk of MACE or death. In conclusion, arterial stiffness may explain part of the association from physical activity to risk of death and potentially risk of MACE in men.

男性和女性的身体活动、动脉僵硬、心血管疾病和死亡风险:一项基于人群的研究
体育活动可以降低心血管疾病的风险,也可以减少动脉僵硬。我们的目的是研究动脉僵硬是否可以部分解释体力活动与男性和女性主要不良心血管事件(MACE)和全因死亡风险之间的关联。我们对来自Malmö饮食与癌症研究(2007-2012)的2583名患者进行了瑞典全国登记(平均随访时间:9年),以了解MACE发生情况。使用问卷对身体活动进行自我评估。动脉硬度以颈-股脉波速度(cfPWV)作为金标准进行评估。采用Cox回归进行生存分析。在所有个体中,每1 m/s高PWV的多变量校正风险比为MACE为1.09(95%置信区间:1.05-1.14),死亡为1.06(1.03-1.09)。经解释的体育活动与动脉僵硬相关的风险估计为MACE风险的12%(0%-100%)和死亡风险的5% (1%-16%);男性相应结果分别为7%(0.4%-28%)和7%(0%-51%)。对于女性来说,体育活动与MACE或死亡风险无关。总之,动脉僵硬可以部分解释体力活动与男性死亡风险和MACE潜在风险之间的关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Angiology
Angiology 医学-外周血管病
CiteScore
5.50
自引率
14.30%
发文量
180
审稿时长
6-12 weeks
期刊介绍: A presentation of original, peer-reviewed original articles, review and case reports relative to all phases of all vascular diseases, Angiology (ANG) offers more than a typical cardiology journal. With approximately 1000 pages per year covering diagnostic methods, therapeutic approaches, and clinical and laboratory research, ANG is among the most informative publications in the field of peripheral vascular and cardiovascular diseases. This journal is a member of the Committee on Publication Ethics (COPE). Average time from submission to first decision: 13 days
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