Drug-eluting vascular stents with surface modification of anticoagulation and pro-endothelialization

IF 5.4 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules Pub Date : 2025-09-24 DOI:10.1021/acs.biomac.5c01382

Mengdi Liang, , , Dulin Zuo, , , Feng Wang, , , Bei Zhang, , , Jingjing Tian, , , Xianchen Huang, , , Yuan Sun, , , Guanqiang Li*, , , Xicheng Zhang*, , and , Gang Li*,

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引用次数: 0

Abstract

Abdominal aortic aneurysm (AAA) treatment relies on covered stents, yet thrombosis, restenosis, and delayed endothelialization remain challenges. This study developed a bifunctional heparin/zwitterionic polymer (CBMA) coating on dopamine-modified stents via surface-initiated atom transfer radical polymerization (SI-ATRP). The coating integrates CBMA’s antifouling properties (98.5% reduction in BSA adsorption) with heparin’s sustained anticoagulation (37% APTT prolongation, 17 s TT increase) and endothelialization promotion (194.97% endothelial cell activity after 5 days). Animal trials confirmed reduced TNF-α expression (75% decrease), enhanced collagen deposition, neovascularization post-28 days, and preserved mechanical strength (diametral tensile strength >57 MPa) with 25% lower permeability. This dual-functional coating offers a novel synergistic strategy for antithrombosis and endothelial repair in clinical applications.

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具有抗凝和促内皮化表面修饰的药物洗脱血管支架。

腹主动脉瘤（AAA）的治疗依赖于覆盖支架，但血栓形成、再狭窄和延迟内皮化仍然是挑战。本研究通过表面引发原子转移自由基聚合（SI-ATRP）在多巴胺修饰支架上制备了双功能肝素/两性离子聚合物（CBMA）涂层。该涂层将CBMA的防污性能（BSA吸附减少98.5%）与肝素的持续抗凝（APTT延长37%，TT增加17 s）和内皮化促进（5天后内皮细胞活性194.97%）结合在一起。动物实验证实，TNF-α表达降低（降低75%），胶原沉积增强，28天后新生血管形成，机械强度（直径抗拉强度>57 MPa）保持不变，通透性降低25%。这种双功能涂层在临床应用中为抗血栓形成和内皮修复提供了一种新的协同策略。

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来源期刊

Biomacromolecules 化学-高分子科学

CiteScore

10.60

自引率

4.80%

发文量

417

审稿时长

1.6 months

期刊介绍： Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.