Advancements in Dissolving Microneedles for Effective Transdermal Delivery in Rheumatoid Arthritis Treatment

IF 4.4 3区 材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Wangrui Peng, MeeiChyn Goh, Jie Lan, Meng Du, Zhiyi Chen
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Abstract

Rheumatoid arthritis (RA) is a prevalent chronic inflammatory disease that causes severe joint damage and dysfunction. Conventional therapeutic approaches, including oral and injectable options, are associated with gastrointestinal adverse effects and infection risks, highlighting the necessity for alternative drug delivery systems. Microneedles have emerged as a promising transdermal drug delivery strategy, effectively penetrating the stratum corneum to enable both topical and systemic administration. Among these, dissolving microneedles (DMNs) stand out due to their biocompatibility, biodegradability, and high drug-loading capacity, making them suitable for RA treatment. However, challenges such as insufficient mechanical strength can limit their efficacy, as skin elasticity may prevent the needles from achieving the necessary depth for effective drug release. This review examines the potential of DMNs as a novel transdermal delivery approach for RA management, exploring differences in materials, delivery strategies, and shapes used in various studies. It analyzes the relationship between these factors and the mechanical properties of the microneedles, ultimately identifying materials and designs that optimize DMNs' performance for effective drug delivery in RA treatment. This study aims to provide valuable insights into the selection of materials and the design of microneedle shapes, facilitating the future development of DMNs for RA or similar diseases.

Abstract Image

溶解微针经皮给药治疗类风湿性关节炎的研究进展
类风湿性关节炎(RA)是一种常见的慢性炎症性疾病,可导致严重的关节损伤和功能障碍。传统的治疗方法,包括口服和注射选择,与胃肠道不良反应和感染风险相关,突出了替代药物输送系统的必要性。微针已成为一种有前途的透皮给药策略,有效地穿透角质层,使局部和全身给药成为可能。其中,溶解微针(DMNs)因其生物相容性、生物可降解性和高载药能力而脱颖而出,适合用于RA的治疗。然而,机械强度不足等挑战会限制它们的功效,因为皮肤弹性可能会阻止针头达到有效释放药物所需的深度。这篇综述探讨了DMNs作为一种新的经皮给药方法治疗RA的潜力,探讨了在各种研究中使用的材料、给药策略和形状的差异。它分析了这些因素与微针力学性能之间的关系,最终确定了优化DMNs性能的材料和设计,以有效地在RA治疗中给药。本研究旨在为材料的选择和微针形状的设计提供有价值的见解,促进未来用于RA或类似疾病的DMNs的发展。
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来源期刊
Advanced Materials Interfaces
Advanced Materials Interfaces CHEMISTRY, MULTIDISCIPLINARY-MATERIALS SCIENCE, MULTIDISCIPLINARY
CiteScore
8.40
自引率
5.60%
发文量
1174
审稿时长
1.3 months
期刊介绍: Advanced Materials Interfaces publishes top-level research on interface technologies and effects. Considering any interface formed between solids, liquids, and gases, the journal ensures an interdisciplinary blend of physics, chemistry, materials science, and life sciences. Advanced Materials Interfaces was launched in 2014 and received an Impact Factor of 4.834 in 2018. The scope of Advanced Materials Interfaces is dedicated to interfaces and surfaces that play an essential role in virtually all materials and devices. Physics, chemistry, materials science and life sciences blend to encourage new, cross-pollinating ideas, which will drive forward our understanding of the processes at the interface. Advanced Materials Interfaces covers all topics in interface-related research: Oil / water separation, Applications of nanostructured materials, 2D materials and heterostructures, Surfaces and interfaces in organic electronic devices, Catalysis and membranes, Self-assembly and nanopatterned surfaces, Composite and coating materials, Biointerfaces for technical and medical applications. Advanced Materials Interfaces provides a forum for topics on surface and interface science with a wide choice of formats: Reviews, Full Papers, and Communications, as well as Progress Reports and Research News.
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