Determinants of Changes in HPV Vaccination Willingness Among Men Who Have Sex With Men: An Observational Cohort Study

IF 4.6 3区医学 Q1 VIROLOGY

Journal of Medical Virology Pub Date : 2025-09-24 DOI:10.1002/jmv.70611

Jingjing He, Tian Tian, Xiaoqing Tuo, Wenhui Yu, Shulipan Asilibieke, Zewen Zhang, Lirong Liu, Miaomiao Xi, Heng Yang, Guozhen Zhang, Jianghong Dai

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Abstract

Human papillomavirus (HPV) infection is highly prevalent among men who have sex with men (MSM) and increases the risk of cancer; however, vaccine uptake remains low. Our objective was to explore the factors influencing changes in HPV vaccination willingness among MSM. HIV-negative MSM aged ≥ 18 years in Xinjiang, China, were enrolled in an observational cohort study conducted from March 1, 2017, to March 30, 2023. A self-administered questionnaire was used to collect baseline and follow-up data every 6 months on HPV vaccination willingness, demographics, sexual behaviors, and HPV knowledge. Anal swabs were used for HPV genotyping. Participants were categorized based on their longitudinal willingness as consistently willing, transitioning, or consistently unwilling. Multivariable logistic regression was used to analyze determinants of changes in vaccination willingness. Among 746 enrolled MSM (median age 30 [IQR:25–36]), 442 (59.2%) were consistently willing to vaccinate, 160 (21.4%) transitioned to willingness, and 144 (19.4%) were consistently unwilling. In multivariate analysis, lower education (high school or below: adjusted odds ratio (AOR) = 2.4, 95% confidence interval (95% CI): 1.4–4.1; some college: AOR = 1.8, 95% CI: 1.1–2.9), lower income (1001–5000 yuan: AOR = 0.39, 95% CI: 0.19–0.77; 5001–10 000 yuan: AOR = 0.26, 95% CI: 0.13–0.54; ≥ 10 001 yuan: AOR = 0.14, 95% CI: 0.05–0.42), and lower HPV knowledge (AOR = 0.6, 95% CI: 0.4–0.9) were independently associated with vaccination willingness. HPV vaccine willingness was low but dynamic among MSM. Addressing modifiable factors, such as HPV knowledge, may improve uptake.

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男男性行为者HPV疫苗接种意愿变化的决定因素：一项观察性队列研究

人乳头瘤病毒（HPV）感染在男男性行为者（MSM）中非常普遍，并增加了患癌症的风险；然而，疫苗接种率仍然很低。我们的目的是探讨影响MSM人群HPV疫苗接种意愿变化的因素。2017年3月1日至2023年3月30日，中国新疆年龄≥18岁的hiv阴性MSM被纳入一项观察性队列研究。一份自我管理的问卷每6个月收集一次关于HPV疫苗接种意愿、人口统计学、性行为和HPV知识的基线和随访数据。肛拭子用于HPV基因分型。参与者根据他们的纵向意愿被分类为一贯愿意、过渡或一贯不愿意。采用多变量logistic回归分析疫苗接种意愿变化的决定因素。在746名入组的MSM（中位年龄为30岁[IQR: 25-36]）中，442人（59.2%）一直愿意接种疫苗，160人（21.4%）转变为愿意接种疫苗，144人（19.4%）一直不愿意接种疫苗。在多变量分析中，低教育程度（高中或以下）：调整优势比(AOR) = 2.4, 95%可信区间（95% CI）： 1.4-4.1；部分高校：AOR = 1.8, 95% CI: 1.1 ~ 2.9)、收入较低（1001 ~ 5000元：AOR = 0.39, 95% CI: 0.19 ~ 0.77； 5001 ~ 10000元：AOR = 0.26, 95% CI: 0.13 ~ 0.54；≥10001元：AOR = 0.14, 95% CI: 0.05 ~ 0.42）、HPV知识较低（AOR = 0.6, 95% CI: 0.4 ~ 0.9）与接种意愿独立相关。男男性接触者的HPV疫苗接种意愿虽低但呈动态变化。解决可改变的因素，如HPV知识，可能会提高摄取。

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来源期刊

Journal of Medical Virology 医学-病毒学

CiteScore

23.20

自引率

2.40%

发文量

777

审稿时长

1 months

期刊介绍： The Journal of Medical Virology focuses on publishing original scientific papers on both basic and applied research related to viruses that affect humans. The journal publishes reports covering a wide range of topics, including the characterization, diagnosis, epidemiology, immunology, and pathogenesis of human virus infections. It also includes studies on virus morphology, genetics, replication, and interactions with host cells. The intended readership of the journal includes virologists, microbiologists, immunologists, infectious disease specialists, diagnostic laboratory technologists, epidemiologists, hematologists, and cell biologists. The Journal of Medical Virology is indexed and abstracted in various databases, including Abstracts in Anthropology (Sage), CABI, AgBiotech News & Information, National Agricultural Library, Biological Abstracts, Embase, Global Health, Web of Science, Veterinary Bulletin, and others.