Iron metabolism study: The characteristics of iron metabolism in patients with ovarian endometriosis complicated with infertility

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research Pub Date : 2025-09-23 DOI:10.1111/jog.70058

Limian Huang, Weiling Qin, Tongye Su, Haiyan Pang, Delong Xie, Jiejie Liao, Xiao Qin

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引用次数: 0

Abstract

Objectives

This study investigates iron metabolism characteristics in patients with ovarian endometriosis (EMs) and infertility.

Methods

A case–control study was conducted involving 76 infertility patients treated at Baise People's Hospital from December 2023 to December 2024. Among them, 36 patients with ovarian EMs and infertility were included in the case group, whereas 40 infertile women without EMs constituted the control group. The indices of iron metabolism, including serum iron (SI), transferrin (TRF), soluble transferrin receptor (sTfR), unsaturated iron binding capacity (UIBC), total iron binding capacity (TIBC), and transferrin saturation (TS), were measured and compared between the two groups. Furthermore, the association between iron metabolism levels and the development and progression of EMs was systematically analyzed.

Results

The SI level was significantly higher in the study group than in the control group (p < 0.01). Levels of TRF, UIBC, and TIBC were significantly lower in the study group compared to the control group (p < 0.001). No significant differences were observed in sTfR or TS between the two groups (p > 0.05). Receiver operating characteristic curve analysis demonstrated that the combined assessment of SI, TRF, UIBC, and TIBC provided statistically significant diagnostic accuracy for differentiating between the two groups, with corresponding p values less than 0.01.

Conclusion

Abnormal iron metabolism is present in patients with EMs and infertility. Excessive iron accumulation may exacerbate disease progression and influence reproductive prognosis. Modulating iron metabolism could potentially serve as a novel strategy to improve the condition of EMs and pregnancy outcomes.

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铁代谢研究：卵巢子宫内膜异位症合并不孕症患者铁代谢特点

目的探讨卵巢子宫内膜异位症（EMs）合并不孕患者的铁代谢特征。方法对2023年12月至2024年12月在百色市人民医院就诊的76例不孕症患者进行病例对照研究。其中36例卵巢EMs合并不孕症患者为病例组，40例无EMs的不孕女性为对照组。测定两组患者血清铁（SI）、转铁蛋白（TRF）、可溶性转铁蛋白受体（sTfR）、不饱和铁结合能力（UIBC）、总铁结合能力（TIBC）、转铁蛋白饱和度（TS）等铁代谢指标，并进行比较。此外，我们还系统分析了铁代谢水平与EMs发生进展之间的关系。结果研究组SI水平明显高于对照组（p < 0.01）。与对照组相比，研究组的TRF、UIBC和TIBC水平显著降低（p < 0.001）。sTfR、TS两组比较差异无统计学意义（p > 0.05）。受试者工作特征曲线分析显示，SI、TRF、UIBC、TIBC联合评估对两组患者的诊断准确率具有统计学意义，p值均小于0.01。结论EMs合并不孕症患者存在铁代谢异常。铁积累过多可加重疾病进展，影响生殖预后。调节铁代谢可能作为一种新的策略来改善EMs的状况和妊娠结局。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.