Research Communication: The Cumulated Spontaneous Portosystemic Shunts (SPSS) Area Decreases After TIPS and Impacts on Prognosis.

IF 6.7 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Alimentary Pharmacology & Therapeutics Pub Date : 2025-09-24 DOI:10.1111/apt.70381

Marlene Hintersteininger,Theresa Müllner-Bucsics,Susanna Riegler,Nina Dominik,Georg Kramer,Christian Sebesta,Paul Thöne,Ulrika Asenbaum,Lukas Reider,Maria Schoder,Michael Trauner,Mattias Mandorfer,Thomas Reiberger,Lukas Hartl,Katharina Lampichler

引用次数: 0

Abstract

We evaluated the dynamics of spontaneous portosystemic shunts (SPSS) after transjugular intrahepatic portosystemic shunt (TIPS). Ninety patients with covered TIPS placement and contrast-enhanced CT scans before and after TIPS were included. Total SPSS area and total shunt area (including TIPS) were assessed. Median SPSS area (67.2-15.7 mm2; p < 0.001) decreased after TIPS, while total shunt area remained unchanged (67.2-75.8 mm2; p = 0.170). Relative SPSS area decrease was an independent protective factor for mortality (asHR: 0.19; 95% CI: 0.04-0.88; p = 0.034). In conclusion, SPSS decrease after TIPS and relative SPSS area change is independently linked to survival, while total shunt area remains unaltered.

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研究交流：TIPS术后累积自发性门静脉分流面积减少及其对预后的影响。

我们评估了经颈静脉肝内门静脉分流术（TIPS）后自发性门静脉分流术（SPSS）的动力学。纳入了90例覆盖TIPS放置和TIPS前后对比增强CT扫描的患者。统计SPSS总面积和分流总面积（包括TIPS）。TIPS后SPSS面积中位数（67.2-15.7 mm2, p < 0.001）减小，而总分流面积保持不变（67.2-75.8 mm2, p = 0.170）。相对SPSS面积减少是死亡率的独立保护因素（asHR: 0.19; 95% CI: 0.04-0.88; p = 0.034）。综上所述，TIPS后SPSS下降和SPSS相对面积变化与生存独立相关，而总分流面积保持不变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alimentary Pharmacology & Therapeutics 医学-胃肠肝病学

CiteScore

15.60

自引率

7.90%

发文量

527

审稿时长

3-6 weeks

期刊介绍： Alimentary Pharmacology & Therapeutics is a global pharmacology journal focused on the impact of drugs on the human gastrointestinal and hepato-biliary systems. It covers a diverse range of topics, often with immediate clinical relevance to its readership.