Topical Dexamethasone During Stapedotomy in Patients With Otosclerosis: A Randomized Clinical Trial.

IF 2 3区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Laryngoscope Pub Date : 2025-09-23 DOI:10.1002/lary.70076

Behrooz Amirzargar, Sepideh Zoafa, Melika Karimi, Saeed Mohammadi, Hamed Emami, Ali Kouhi, Saeed Golparvaran

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引用次数: 0

Abstract

Objectives: To investigate the effect of topical dexamethasone on improving hearing outcomes and alleviating postoperative symptoms in patients diagnosed with otosclerosis who have undergone stapedotomy.

Study design: Randomized, single-blinded clinical trial METHODS: Seventy patients diagnosed with otosclerosis were randomly divided into intervention and control groups and underwent stapedotomy with or without topical dexamethasone, respectively. Hearing outcomes and postoperative pain, vertigo, and tinnitus were compared.

Results: The mean improvement in the air-bone gap (ABG) was 23.53 ± 8.70 dB in the intervention group and 18.95 ± 11.66 dB in the control group, with no statistically significant difference between the two groups (0.087). Speech Reception Threshold (SRT) and Word Recognition Score (WRS) improved more significantly in the dexamethasone group (p < 0.001 and p = 0.004, respectively). Postoperative tinnitus and vertigo were significantly lower in the dexamethasone group (p = 0.032 and p < 0.001, respectively).

Conclusion: Applying dexamethasone during stapedotomy can reduce post-operative vertigo and tinnitus. Although hearing outcomes were better in the intervention group, there was no statistically significant difference in ABG improvement between the two groups.

Level of evidence: 2:

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耳硬化症患者镫骨切除术时局部地塞米松：一项随机临床试验。

目的：探讨外用地塞米松对镫骨切除术后耳硬化症患者听力结局及术后症状的影响。方法：将70例确诊为耳硬化症的患者随机分为干预组和对照组，分别行镫骨切开术加地塞米松或不加地塞米松治疗。比较了听力结果和术后疼痛、眩晕和耳鸣。结果：干预组空气-骨间隙（ABG）平均改善23.53±8.70 dB，对照组平均改善18.95±11.66 dB，两组差异无统计学意义（0.087）。地塞米松组患者语音接收阈值（SRT）和单词识别评分（WRS）的改善更为显著(p)。结论：镫骨切除术中应用地塞米松可减轻术后眩晕和耳鸣。虽然干预组的听力结果更好，但两组之间的ABG改善无统计学差异。证据等级:2;

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来源期刊

Laryngoscope 医学-耳鼻喉科学

CiteScore

6.50

自引率

7.70%

发文量

500

审稿时长

2-4 weeks

期刊介绍： The Laryngoscope has been the leading source of information on advances in the diagnosis and treatment of head and neck disorders since 1890. The Laryngoscope is the first choice among otolaryngologists for publication of their important findings and techniques. Each monthly issue of The Laryngoscope features peer-reviewed medical, clinical, and research contributions in general otolaryngology, allergy/rhinology, otology/neurotology, laryngology/bronchoesophagology, head and neck surgery, sleep medicine, pediatric otolaryngology, facial plastics and reconstructive surgery, oncology, and communicative disorders. Contributions include papers and posters presented at the Annual and Section Meetings of the Triological Society, as well as independent papers, "How I Do It", "Triological Best Practice" articles, and contemporary reviews. Theses authored by the Triological Society’s new Fellows as well as papers presented at meetings of the American Laryngological Association are published in The Laryngoscope. • Broncho-esophagology • Communicative disorders • Head and neck surgery • Plastic and reconstructive facial surgery • Oncology • Speech and hearing defects