Current findings and potential applications of cell death research in ovarian cancer.

Abstract

One of the top gynecological health problems for women is ovarian cancer (OC) and it causes a huge disease burden not only for women but for all of humanity. The disease's immense burden comes from it often detected at advanced stages, current treatments such as chemotherapy or radiotherapy are not very effective, leading to a low 5-year survival rate. Therefore, discovering new therapeutic approaches that target the processes contributing to ovarian tumor formation and metastasis is urgently needed. Among them, regulating cell death processes is emerging as a promising therapy for eliminating cancer including ovarian cancer. Many scientists have been researching and clinically testing methods and drug molecules to control cell death processes consisting of apoptosis, necroptosis, ferroptosis, cuproptosis, or pyroptosis to destroy tumors. In this work, we displayed an overview about the importance of cell death in the control of ovarian carcinoma cells. According to the current knowledge of the mechanisms of cell death, targeted drugs and approaches have been studied to modulate the activation/inhibition of this process in the treatment of ovarian tumor. Thanks to that, new hopes are explored to help improve the effectiveness of cancer diagnosis and treatment.