Functional and Neurophysiological Changes After Activities-Based Locomotor Training in Children With Cerebral Palsy: Case Series.

IF 1.5 4区医学 Q3 PEDIATRICS

Pediatric Physical Therapy Pub Date : 2025-09-17 DOI:10.1097/PEP.0000000000001265

Megan B Flores, Elizabeth M Ardolino, Cierra B Ugale, Cory M Smith

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引用次数: 0

Abstract

Purpose: The purpose of this case series was to explore the feasibility and impact of a 3-week activities-based locomotor training (AB-LT) program on functional activities and neurophysiological adaptations in 5 children with cerebral palsy (CP).

Methods: Children, aged 2-6 years who were classified as Gross Motor Function Classification Scale levels III or IV, participated in the intervention 5 days per week for 3 hours per day. The Gross Motor Function Measure-66 (GMFM-66) and functional near-infrared spectroscopy neuroimaging were performed pre- and post-intervention.

Results: After AB-LT, increases in GMFM-66 scores were observed for Children 1 (Δ3.3), 2 (Δ5.6), 4 (Δ1.8), and 5 (Δ1.3), beyond expected natural progression. A reduction in total hemoglobin activation and increased neural demand was observed. Child 3 had minimal functional changes with no observed neurophysiological adaptations.

Conclusions: The 3-week AB-LT regimen is a short duration, high-intensity program with the potential to benefit children with CP.

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脑性麻痹儿童运动训练后的功能和神经生理变化：病例系列。

目的：本研究旨在探讨为期3周的运动训练（AB-LT）对5例脑瘫（CP）患儿功能活动和神经生理适应的可行性和影响。方法：2-6岁大运动功能分级量表III级或IV级儿童，每周5天，每天3小时进行干预。在干预前后分别进行大运动功能测量-66 （GMFM-66）和功能性近红外光谱神经成像。结果：在AB-LT后，观察到儿童1 （Δ3.3）， 2 （Δ5.6）， 4 （Δ1.8）和5 （Δ1.3）的GMFM-66评分增加，超出预期的自然进展。观察到总血红蛋白活性降低和神经需求增加。儿童3的功能变化很小，没有观察到神经生理适应。结论：3周的AB-LT方案是一个短时间、高强度的方案，有可能使CP患儿受益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Physical Therapy PEDIATRICS-REHABILITATION

CiteScore

1.50

自引率

18.80%

发文量

147

审稿时长

>12 weeks

期刊介绍： Pediatric Physical Therapy is an indexed international journal, that publishes peer reviewed research related to the practice of physical therapy for children with movement disorders. The editorial board is comprised of an international panel of researchers and clinical scholars that oversees a rigorous peer review process. The journal serves as the official journal for the pediatric physical therapy professional organizations in the Netherlands, Switzerland, New Zealand, Canada, and the United States. The journal includes articles that support evidenced based practice of physical therapy for children with neuromuscular, musculoskeletal, cardiorespiratory and developmental conditions that lead to disorders of movement, and research reports that contribute to the foundational sciences of pediatric physical therapy, ranging from biomechanics and pediatric exercise science to neurodevelopmental science. To these ends the journal publishes original research articles, systematic reviews directed to specific clinical questions that further the science of physical therapy, clinical guidelines and case reports that describe unusual conditions or cutting edge interventions with sound rationale. The journal adheres to the ethical standards of theInternational Committee of Medical Journal Editors.