Cell death mechanisms during Mycobacterium tuberculosis infection: A perspective from a host-pathogen interface.

3区 生物学 Q2 Biochemistry, Genetics and Molecular Biology
Prachi Nangpal, Nupur Angrish, Garima Khare
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引用次数: 0

Abstract

Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is a life threatening disease, which accounts for millions of lives annually. Mtb is an intracellular bacterium, has coevolved with humans to premeditate its machinery to surpass the immunity mounted against it in order to persist for long durations in the system. Cell death is a fundamental process required not only for tissue homeostasis but also for providing protection against intracellular pathogens. Various forms of cell death processes are known including apoptosis, pyroptosis, necroptosis, autophagy etc., that have been shown to play important roles in anti-TB immunity against Mtb. Moreover, inhibition of these pathways by Mtb is considered as one of the virulence mechanisms by which the pathogen is able to survive and replicate inside the host. Apart from identification of newer drug targets and development of anti-TB drugs that solely target the pathogen, recent advancements have been made in developing host-directed therapies against TB, which are aimed at modulating the host responses to reduce excessive inflammation and tissue damage. Thus, understanding the proteins and signaling cascades associated with cell death modalities and their relation with Mtb infection will give us new insights into the area of host-pathogen interactions and help us design better host-directed therapies.

结核分枝杆菌感染期间的细胞死亡机制:从宿主-病原体界面的视角。
由结核分枝杆菌(Mtb)引起的结核病是一种威胁生命的疾病,每年夺去数百万人的生命。结核分枝杆菌是一种细胞内细菌,与人类共同进化,预先设计了它的机制,以超越对它的免疫,以便在系统中持续很长时间。细胞死亡是一个基本的过程,不仅需要组织稳态,而且提供保护,防止细胞内病原体。已知多种形式的细胞死亡过程,包括细胞凋亡、焦亡、坏死亡、自噬等,已被证明在抗结核免疫中发挥重要作用。此外,Mtb对这些途径的抑制被认为是病原体能够在宿主内存活和复制的毒力机制之一。除了确定新的药物靶点和开发仅针对病原体的抗结核药物外,最近在开发针对结核病的宿主定向疗法方面取得了进展,这些疗法旨在调节宿主反应以减少过度炎症和组织损伤。因此,了解与细胞死亡模式相关的蛋白质和信号级联及其与结核分枝杆菌感染的关系将为我们提供宿主-病原体相互作用领域的新见解,并帮助我们设计更好的宿主定向治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.00
自引率
0.00%
发文量
110
审稿时长
4-8 weeks
期刊介绍: Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientific importance. If today you read an Article or Letter in Nature or a Research Article or Report in Science reporting findings of exceptional importance, you likely will find comprehensive coverage of that research area in a future PMBTS volume.
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