POSSIBLE PREVENTION OF NEURODEVELOPMENTAL CONSEQUENCES OF VERTICAL HIV TRANSMISSION IN EARLY CHILDHOOD? A SYSTEMATIC REVIEW.

4区医学 Q2 Medicine

Psychiatria Danubina Pub Date : 2025-09-01

Johanna Muhigana, Rwego Antoine Gasasira, Hélène Nicolis

{"title":"POSSIBLE PREVENTION OF NEURODEVELOPMENTAL CONSEQUENCES OF VERTICAL HIV TRANSMISSION IN EARLY CHILDHOOD? A SYSTEMATIC REVIEW.","authors":"Johanna Muhigana, Rwego Antoine Gasasira, Hélène Nicolis","doi":"","DOIUrl":null,"url":null,"abstract":"Background: Children infected with the Human Immunodeficiency Virus (HIV) exhibit the lowest neurodevelopmental scores. Mother-to-child-transmission prevention include perinatally and early antiretroviral therapy (ART) although long-term effects of in utero exposure to ART on neurodevelopment remain unclear. It was difficult to determine whether these reported neurodevelopmental scores were a direct result of HIV.Methods: A systematic search was conducted to identify the environmental and neurobiological factors associated with HIV infection and their impact on neurodevelopment. It was carried out across four electronic databases: Scopus, PubMed, ProQuest and Cochrane Database of Systematic Reviews. We selected 15 articles published between 2012 and 2024.Results: Regarding ART, 4 articles reported a positive effect of ART regardless of the age of initiation and duration. We couldn't identify caregiver distress as a risk factor.Conclusions: Further research should include large cohort studies assessing long term consequences of ART exposition on children's neurodevelopment and impact of caregiver distress on child neurodevelopmental outcomes.","PeriodicalId":20760,"journal":{"name":"Psychiatria Danubina","volume":"37 Suppl 1","pages":"135-139"},"PeriodicalIF":0.0000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychiatria Danubina","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Children infected with the Human Immunodeficiency Virus (HIV) exhibit the lowest neurodevelopmental scores. Mother-to-child-transmission prevention include perinatally and early antiretroviral therapy (ART) although long-term effects of in utero exposure to ART on neurodevelopment remain unclear. It was difficult to determine whether these reported neurodevelopmental scores were a direct result of HIV.

Methods: A systematic search was conducted to identify the environmental and neurobiological factors associated with HIV infection and their impact on neurodevelopment. It was carried out across four electronic databases: Scopus, PubMed, ProQuest and Cochrane Database of Systematic Reviews. We selected 15 articles published between 2012 and 2024.

Results: Regarding ART, 4 articles reported a positive effect of ART regardless of the age of initiation and duration. We couldn't identify caregiver distress as a risk factor.

Conclusions: Further research should include large cohort studies assessing long term consequences of ART exposition on children's neurodevelopment and impact of caregiver distress on child neurodevelopmental outcomes.

本刊更多论文

预防幼儿HIV垂直传播对神经发育的影响？系统回顾。

背景：感染人类免疫缺陷病毒（HIV）的儿童表现出最低的神经发育评分。预防母婴传播包括围产期和早期抗逆转录病毒治疗（ART），尽管子宫内接触抗逆转录病毒治疗对神经发育的长期影响尚不清楚。很难确定这些报道的神经发育评分是否是HIV的直接结果。方法：系统研究HIV感染相关的环境和神经生物学因素及其对神经发育的影响。研究通过四个电子数据库进行：Scopus、PubMed、ProQuest和Cochrane系统评价数据库。我们选择了2012年至2024年间发表的15篇文章。结果：关于ART， 4篇文章报道了ART的积极效果，无论开始年龄和持续时间如何。我们不能确定看护人的痛苦是一个风险因素。结论：进一步的研究应包括大型队列研究，评估抗逆转录病毒治疗对儿童神经发育的长期影响，以及照顾者痛苦对儿童神经发育结果的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Psychiatria Danubina 医学-精神病学

CiteScore

3.00

自引率

0.00%

发文量

288

审稿时长

4-8 weeks

期刊介绍： Psychiatria Danubina is a peer-reviewed open access journal of the Psychiatric Danubian Association, aimed to publish original scientific contributions in psychiatry, psychological medicine and related science (neurosciences, biological, psychological, and social sciences as well as philosophy of science and medical ethics, history, organization and economics of mental health services).