Neurodevelopmental disorders in children with congenital abdominal wall defects: a national population-based study.

IF 1.6 3区医学 Q2 PEDIATRICS

Pediatric Surgery International Pub Date : 2025-09-22 DOI:10.1007/s00383-025-06201-9

Anna Fogelström, Charlotte Skoglund, Eva Hagel, Tomas Wester, Anna Löf Granström, Carmen Mesas-Burgos

{"title":"Neurodevelopmental disorders in children with congenital abdominal wall defects: a national population-based study.","authors":"Anna Fogelström, Charlotte Skoglund, Eva Hagel, Tomas Wester, Anna Löf Granström, Carmen Mesas-Burgos","doi":"10.1007/s00383-025-06201-9","DOIUrl":null,"url":null,"abstract":"Purpose: One in 4000 Swedish children is born with abdominal wall defect (AWD). Little is known about their neurodevelopmental trajectory and long-term morbidity. The aim was to determine the risk of neurodevelopmental disorders in children born with omphalocele or gastroschisis.Methods: This was a population-based national cohort study including children born with omphalocele or gastroschisis in Sweden 1997-2016. Individuals with chromosomal abnormality were excluded. Ten age and sex-matched unexposed individuals were randomly selected for every AWD case. Main outcomes were autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). Data were collected from the national health registers.Results: During the study period, 496 children were born with AWD and included in the exposed cohorts. The unexposed cohorts consisted of 4943 children. Neurodevelopmental diagnoses were found in 11 (6.1%) children with omphalocele and 15 (4.8%) children with gastroschisis compared to 63 (3.5%) and 113 (3.6%) in the unexposed cohorts (p = 0.096 and p = 0.275). Children with omphalocele had higher risk of ASD (HR = 3.51, 95% CI 1.59-7.78) than unexposed peers (p = 0.02). There was no significant difference in ADHD incidence.Conclusions: Children with AWD may have similar risk of ADHD as age- and sex-matched peers. While the omphalocele cohort had a higher incidence of ASD, the overall incidence remained relatively low.Level of evidence: II.","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"303"},"PeriodicalIF":1.6000,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454545/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Surgery International","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00383-025-06201-9","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PEDIATRICS","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: One in 4000 Swedish children is born with abdominal wall defect (AWD). Little is known about their neurodevelopmental trajectory and long-term morbidity. The aim was to determine the risk of neurodevelopmental disorders in children born with omphalocele or gastroschisis.

Methods: This was a population-based national cohort study including children born with omphalocele or gastroschisis in Sweden 1997-2016. Individuals with chromosomal abnormality were excluded. Ten age and sex-matched unexposed individuals were randomly selected for every AWD case. Main outcomes were autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). Data were collected from the national health registers.

Results: During the study period, 496 children were born with AWD and included in the exposed cohorts. The unexposed cohorts consisted of 4943 children. Neurodevelopmental diagnoses were found in 11 (6.1%) children with omphalocele and 15 (4.8%) children with gastroschisis compared to 63 (3.5%) and 113 (3.6%) in the unexposed cohorts (p = 0.096 and p = 0.275). Children with omphalocele had higher risk of ASD (HR = 3.51, 95% CI 1.59-7.78) than unexposed peers (p = 0.02). There was no significant difference in ADHD incidence.

Conclusions: Children with AWD may have similar risk of ADHD as age- and sex-matched peers. While the omphalocele cohort had a higher incidence of ASD, the overall incidence remained relatively low.

Level of evidence: II.

查看原文本刊更多论文

先天性腹壁缺损儿童的神经发育障碍：一项基于全国人群的研究。

目的：每4000名瑞典儿童中就有1名患有腹壁缺陷（AWD）。他们的神经发育轨迹和长期发病率知之甚少。目的是确定患有脐膨出或胃裂的儿童患神经发育障碍的风险。方法：这是一项以人群为基础的国家队列研究，包括1997-2016年瑞典出生时患有脐膨出或胃裂的儿童。排除有染色体异常的个体。每个AWD病例随机选择10个年龄和性别匹配的未暴露个体。主要结局为自闭症谱系障碍（ASD）和注意缺陷/多动障碍（ADHD）。数据是从国家健康登记册收集的。结果：在研究期间，496名出生时患有AWD的儿童被纳入暴露队列。未暴露的队列由4943名儿童组成。11名脐膨出儿童（6.1%）和15名腹裂儿童（4.8%）被诊断为神经发育，而未暴露组分别为63名（3.5%）和113名（3.6%）（p = 0.096和p = 0.275）。脐膨出儿童患ASD的风险高于未暴露儿童（HR = 3.51, 95% CI 1.59-7.78）（p = 0.02）。两组ADHD发生率无显著差异。结论：患有AWD的儿童可能与年龄和性别匹配的同龄人有相似的ADHD风险。虽然脐膨出组的ASD发病率较高，但总体发病率仍然相对较低。证据水平：II。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Pediatric Surgery International 医学-外科

CiteScore

3.00

自引率

5.60%

发文量

215

审稿时长

3-6 weeks

期刊介绍： Pediatric Surgery International is a journal devoted to the publication of new and important information from the entire spectrum of pediatric surgery. The major purpose of the journal is to promote postgraduate training and further education in the surgery of infants and children. The contents will include articles in clinical and experimental surgery, as well as related fields. One section of each issue is devoted to a special topic, with invited contributions from recognized authorities. Other sections will include: -Review articles- Original articles- Technical innovations- Letters to the editor