Gold Nanoparticles in Atherosclerosis: A Dual Approach to Diagnosis and Therapy.

IF 2.5 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Molecular Imaging and Biology Pub Date : 2025-09-22 DOI:10.1007/s11307-025-02050-z

Elaheh Mirhadi, Prashant Kesharwani, Vasily N Sukhorukov, Amirhossein Sahebkar

引用次数: 0

Abstract

Atherosclerosis (AS) is a chronic condition defined by the accumulation of plaque fundamentally resulting from the deposition of low-density lipoprotein and fibrous compounds within injured arteries. Current treatments for atherosclerosis are effective, but the complex and not fully understood underlying mechanisms limit their effectiveness. Moreover, early detection of AS continues to be a real challenge. Innovative therapeutic approaches, such as the application of nanomedicines and theragnostic, are increasingly attracting the interest of researchers globally. Gold nanoparticles (AuNPs) exhibit significant potential as theragnostic agents in the context of atherosclerosis, providing both diagnostic and therapeutic functionalities. This review will discuss current strategies utilizing AuNPs and explore potential future advancements involving theragnostic AuNPs that may aid in addressing AS.

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金纳米颗粒在动脉粥样硬化中的应用：诊断和治疗的双重途径。

动脉粥样硬化（AS）是一种慢性疾病，主要由损伤动脉内低密度脂蛋白和纤维化合物沉积引起斑块积聚。目前的动脉粥样硬化治疗是有效的，但复杂且未完全了解的潜在机制限制了其有效性。此外，早期发现AS仍然是一个真正的挑战。创新的治疗方法，如纳米药物和治疗诊断的应用，正日益引起全球研究人员的兴趣。金纳米颗粒（AuNPs）在动脉粥样硬化中具有诊断和治疗双重功能，具有重要的诊断潜力。本综述将讨论目前利用aunp的策略，并探讨可能有助于解决AS的治疗诊断性aunp的潜在未来进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Imaging and Biology 医学-核医学

CiteScore

6.90

自引率

3.20%

发文量

审稿时长

3 months

期刊介绍： Molecular Imaging and Biology (MIB) invites original contributions (research articles, review articles, commentaries, etc.) on the utilization of molecular imaging (i.e., nuclear imaging, optical imaging, autoradiography and pathology, MRI, MPI, ultrasound imaging, radiomics/genomics etc.) to investigate questions related to biology and health. The objective of MIB is to provide a forum to the discovery of molecular mechanisms of disease through the use of imaging techniques. We aim to investigate the biological nature of disease in patients and establish new molecular imaging diagnostic and therapy procedures. Some areas that are covered are: Preclinical and clinical imaging of macromolecular targets (e.g., genes, receptors, enzymes) involved in significant biological processes. The design, characterization, and study of new molecular imaging probes and contrast agents for the functional interrogation of macromolecular targets. Development and evaluation of imaging systems including instrumentation, image reconstruction algorithms, image analysis, and display. Development of molecular assay approaches leading to quantification of the biological information obtained in molecular imaging. Study of in vivo animal models of disease for the development of new molecular diagnostics and therapeutics. Extension of in vitro and in vivo discoveries using disease models, into well designed clinical research investigations. Clinical molecular imaging involving clinical investigations, clinical trials and medical management or cost-effectiveness studies.