Associations of serum n-6 polyunsaturated fatty acid concentrations with heart rate-corrected QT and JT intervals in middle-aged males.

IF 3.8 3区医学 Q2 NUTRITION & DIETETICS

Journal of Nutrition Pub Date : 2025-09-20 DOI:10.1016/j.tjnut.2025.09.012

Haleh Esmaili, Behnam Tajik, Tomi-Pekka Tuomainen, Jussi Kauhanen, Sudhir Kurl, Jukka T Salonen, Jyrki K Virtanen

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引用次数: 0

Abstract

Background: Although n-6 polyunsaturated fatty acids (PUFAs), particularly the main n-6 PUFA linoleic acid (LA), have been shown to be inversely related to cardiovascular disease (CVD) risk, their associations with ventricular repolarization, a marker of ventricular arrhythmias, remain unclear.

Objective: This study examined the relationships between serum n-6 PUFA concentrations and heart rate-corrected QT (QTc) and JT (JTc) intervals.

Methods: This cross-sectional study included 1,420 Finnish males (aged 42-60 years) free of CVD from the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD). Fasting serum n-6 PUFA concentrations were determined by gas chromatography, and electrocardiographic intervals were automatically derived. QTc and JTc intervals were calculated using Bazett's formula. Associations were analyzed using multivariable-adjusted ANCOVA and logistic regression.

Results: Higher serum total n-6 PUFA concentrations were associated with shorter QTc and JTc intervals (QTc: extreme-quartile difference = -3.36 ms; 95% CI -6.69, -0.41; P-trend = 0.02; JTc: extreme-quartile difference = -3.38 ms; 95% CI -6.79, -0.27; P-trend = 0.03). Similar inverse associations were found for serum LA (QTc: -4.64 ms; 95% CI -8.00, -1.27; P-trend = 0.009; JTc: -3.99 ms; 95% CI -7.44, -0.54; P-trend = 0.02). The other n-6 PUFAs gamma-linolenic acid, dihomo-gamma-linolenic acid and arachidonic acid showed no significant associations.

Conclusions: Higher serum total n-6 PUFA and LA concentrations were associated with shorter QTc and JTc intervals, suggesting a potential protective effect on ventricular arrythmias.

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中年男性血清n-6多不饱和脂肪酸浓度与心率校正QT和JT间期的关系

背景：尽管n-6多不饱和脂肪酸（PUFAs），特别是主要的n-6多不饱和脂肪酸亚油酸（LA），已被证明与心血管疾病（CVD）风险呈负相关，但它们与室性心律失常的标志——心室复极的关系仍不清楚。目的：探讨血清n-6 PUFA浓度与心率校正QT （QTc）和JT （JTc）间期的关系。方法：这项横断面研究包括来自Kuopio缺血性心脏病危险因素研究（KIHD）的1,420名无CVD的芬兰男性（42-60岁）。采用气相色谱法测定空腹血清n-6 PUFA浓度，并自动导出心电图间期。QTc和JTc区间采用Bazett公式计算。使用多变量调整ANCOVA和逻辑回归分析相关性。结果：血清总n-6 PUFA浓度越高，QTc和JTc间隔越短（QTc：极值四分位数差= -3.36 ms; 95% CI -6.69, -0.41; P-trend = 0.02； JTc：极值四分位数差= -3.38 ms; 95% CI -6.79, -0.27; P-trend = 0.03）。血清LA呈类似的负相关（QTc: -4.64 ms; 95% CI: -8.00, -1.27; P-trend = 0.009; JTc: -3.99 ms; 95% CI: -7.44, -0.54; P-trend = 0.02）。其他n-6 PUFAs -亚麻酸、二同-亚麻酸和花生四烯酸无显著相关性。结论：较高的血清总n-6 PUFA和LA浓度与较短的QTc和JTc间隔相关，提示对室性心律失常具有潜在的保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nutrition 医学-营养学

CiteScore

7.60

自引率

4.80%

发文量

260

审稿时长

39 days

期刊介绍： The Journal of Nutrition (JN/J Nutr) publishes peer-reviewed original research papers covering all aspects of experimental nutrition in humans and other animal species; special articles such as reviews and biographies of prominent nutrition scientists; and issues, opinions, and commentaries on controversial issues in nutrition. Supplements are frequently published to provide extended discussion of topics of special interest.