Occlusal features in individuals with cerebral palsy: a systematic review and meta-analysis.

IF 2.7 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

European journal of orthodontics Pub Date : 2025-09-17 DOI:10.1093/ejo/cjaf070

Anna Carolina Rye Sato Kimura, Victor Zanetti Drumond, Mariana Gomes Oliveira, Sicília Rezende Oliveira, Ricardo Alves Mesquita, José Alcides Almeida de Arruda, Lucas Guimarães Abreu

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引用次数: 0

Abstract

Background: Cerebral palsy (CP) results from developmental abnormalities or brain lesions that impair movement, posture, and motor function, thereby affecting skeletal development, including craniofacial structures.

Objectives: This study aimed to evaluate occlusal characteristics in individuals with and without CP.

Search methods: This systematic review followed Meta-Analysis of Observational Studies in Epidemiology guidelines. A comprehensive search was conducted in Embase, PubMed, Web of Science, Ovid, and Scopus, with additional screening of Google Scholar and OpenGrey.

Selection criteria: Observational studies were included, and the risk of bias was assessed using Newcastle-Ottawa Scale.

Data collection and analysis: Meta-analyses were performed to estimate odds ratios (ORs) with 95% confidence intervals (CIs) and prediction intervals. The GRADE approach was used to evaluate the certainty of the evidence.

Results: Of the 584 records identified, 24 cross-sectional studies met the inclusion criteria. Risk-of-bias assessment revealed concerns related to exposure appraisal, nonrespondent characterization, and study comparability. The meta-analysis indicated that individuals with CP had a higher likelihood of Class II malocclusion (OR = 2.56, 95% CI: 1.49-4.38, k = 18) and open bite (OR = 4.27, 95% CI: 1.95-9.37, k = 9).

Conclusions: Individuals with CP are at increased risk of developing Class II malocclusion and open bite, possibly due to neuromuscular dysfunctions and extrinsic factors. Effective management requires a multidisciplinary approach that addresses both biological and behavioral determinants.

Registration: PROSPERO CRD42024551180.

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脑瘫患者的咬合特征：系统回顾和荟萃分析。

背景：脑瘫（CP）是由于发育异常或脑部病变损害运动、姿势和运动功能，从而影响骨骼发育，包括颅面结构。目的：本研究旨在评估患有和未患有cp的个体的咬合特征。检索方法：本系统综述遵循流行病学指南中观察性研究的荟萃分析。在Embase、PubMed、Web of Science、Ovid和Scopus中进行了综合检索，并对谷歌Scholar和OpenGrey进行了额外筛选。选择标准：纳入观察性研究，使用纽卡斯尔-渥太华量表评估偏倚风险。数据收集和分析：进行meta分析，以95%置信区间（ci）和预测区间估计优势比（ORs）。GRADE方法用于评估证据的确定性。结果：在确定的584份记录中，24份横断面研究符合纳入标准。偏倚风险评估揭示了与暴露评估、非被调查者特征和研究可比性相关的问题。荟萃分析显示，CP患者发生II类错颌合（OR = 2.56, 95% CI: 1.49-4.38, k = 18）和开咬（OR = 4.27, 95% CI: 1.95-9.37, k = 9）的可能性更高。结论：CP患者发生II类错颌合和开咬的风险增加，可能是由于神经肌肉功能障碍和外在因素。有效的管理需要一个多学科的方法，解决生物和行为的决定因素。注册号：PROSPERO CRD42024551180。

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来源期刊

European journal of orthodontics 医学-牙科与口腔外科

CiteScore

5.50

自引率

7.70%

发文量

审稿时长

4-8 weeks

期刊介绍： The European Journal of Orthodontics publishes papers of excellence on all aspects of orthodontics including craniofacial development and growth. The emphasis of the journal is on full research papers. Succinct and carefully prepared papers are favoured in terms of impact as well as readability.