Soluble receptor for advanced glycation end product (sRAGE) levels in adolescents with obesity, insulin resistance and metabolic syndrome: A case-control study and the review of the literature.

IF 3.3 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Pembe Soylu Ustkoyuncu, Derya Kocer
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Abstract

Objective: The aim of this study is to evaluate sRAGE levels in adolescents with obesity, and to determine the relationship between sRAGE, insulin resistance, and metabolic syndrome in a case-control study.

Methods: Thirty adolescents with insulin resistance, 28 adolescents without insulin resistance between 10 and 18 years old and 30 Healthy gender and age matched control group were included in the study. Patients with a body mass index z-score above 2, comprised the obesity group. HOMA-IR value above 3.16 was accepted as insulin resistance. Metabolic syndrome was defined based on the International Diabetes Federation definition.

Results: sRAGE levels of the both groups with obesity were lower than control and they were negative correlated with weight, body mass index, C-reactive protein, uric acid, diastolic blood pressure, waist circumference, waist circumference/height ratio and white blood cell count. There were no significant differences in sRAGE levels between adolescents with or without metabolic syndrome, nor between boys and girls. Also, there were no significant differences in sRAGE levels between with or without insulin resistance.

Conclusions: sRAGE levels of the adolescents with obesity decreased. There was no difference in sRAGE levels between those with insulin resistance and metabolic syndrome compared to those without. Metabolic complications associated with obesity are important in terms of causing mortality and morbidity. Understanding the mechanisms could help to identify therapeutic strategies.

Trial registration: NCT06771986| | https://www.

Clinicaltrials: gov/ . Clinical Trial Registration Date: 2025/01/13.

肥胖、胰岛素抵抗和代谢综合征青少年晚期糖基化终产物(sRAGE)可溶性受体水平:一项病例对照研究和文献综述
目的:本研究的目的是在一项病例对照研究中评估肥胖青少年的sRAGE水平,并确定sRAGE与胰岛素抵抗和代谢综合征之间的关系。方法:选取10 ~ 18岁胰岛素抵抗青少年30例、非胰岛素抵抗青少年28例和性别年龄匹配的健康对照组30例作为研究对象。体重指数大于2的患者为肥胖组。HOMA-IR值大于3.16为胰岛素抵抗。代谢综合征的定义是根据国际糖尿病联合会的定义。结果:两组肥胖患者的sRAGE水平均低于对照组,且与体重、体质指数、c反应蛋白、尿酸、舒张压、腰围、腰高比、白细胞计数呈负相关。在有或没有代谢综合征的青少年之间,男孩和女孩之间,sRAGE水平没有显著差异。此外,在有或没有胰岛素抵抗之间,sRAGE水平没有显著差异。结论:肥胖青少年的sRAGE水平下降。与没有胰岛素抵抗和代谢综合征的人相比,胰岛素抵抗和代谢综合征患者的sRAGE水平没有差异。与肥胖相关的代谢并发症在引起死亡率和发病率方面是重要的。了解这些机制有助于确定治疗策略。试验注册:NCT06771986| | https://www.Clinicaltrials: gov/。临床试验注册日期:2013年1月25日。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Endocrine Disorders
BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
280
审稿时长
>12 weeks
期刊介绍: BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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