Annefleur C Langedijk, Floris van den Dungen, Lisette Harteveld, Lisanne van Leeuwen, Lucy Smit, Jennie van den Boer, Diana Mendes, M Claire Verhage, Elise Kocks, Marlies van Houten
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引用次数: 0
Abstract
Introduction: Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infection in infants. This study examined the preferences of Dutch parents and expectant parents for two RSV prevention strategies for infant protection: a maternal vaccine versus an infant monoclonal antibody (mAb) injection.
Methods: An online survey including a discrete choice experiment was conducted. Participants chose between two immunisation options for 'a common virus among infants' that represented RSV. These differed based on six attributes: timing and recipient of the injection, costs, recommended by a healthcare provider (HCP), included in the National Immunisation Programme (NIP), administration location, and co-administered with other injections. The main outcomes were preference weights, conditional relative attribute importance (CRAI), and willingness to be immunised.
Results: The survey was completed by 150 participants (90% female; 49% parents; 51% expectant parents; mean age 31.23 ± 5.61 years). Participants preferred an immunisation option that is administered to pregnant women [mean = 1.48 (95% confidence interval (CI) 1.18-1.82)], free of charge [mean = 1.36 (95% CI 1.10-1.67)], recommended by an HCP [mean = 0.50 (95% CI, 0.34-0.66)], and included in the NIP [mean = 0.42 (95% CI, 0.26-0.58)]. The most important attributes were timing and recipient of the injection [CRAI = 32% (95% CI, 28-35%)] and costs [CRAI = 24% (95% CI, 20-28%)]. Willingness to be immunised was higher when the maternal vaccine and infant mAb injection were in the NIP than when only the infant mAb injection was available (89% vs 74%).
Conclusions: The results suggest that most Dutch parents and expectant parents would prefer a maternal vaccine to an infant mAb injection to immunise their infants against an RSV-like virus. An NIP that incorporates both strategies may enhance uptake and protect the most infants. However, as the attributes were not exhaustively or explicitly presented in the context of RSV prevention, the results may not be completely transferable.
期刊介绍:
Infectious Diseases and Therapy is an international, open access, peer-reviewed, rapid publication journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of infectious disease therapies and interventions, including vaccines and devices. Studies relating to diagnostic products and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged.
Areas of focus include, but are not limited to, bacterial and fungal infections, viral infections (including HIV/AIDS and hepatitis), parasitological diseases, tuberculosis and other mycobacterial diseases, vaccinations and other interventions, and drug-resistance, chronic infections, epidemiology and tropical, emergent, pediatric, dermal and sexually-transmitted diseases.