Effect of Kidney Transplant Type on Coronary Endothelial Function in Individuals with Chronic Kidney Disease.

IF 1.4 4区医学 Q3 SURGERY

Annals of Transplantation Pub Date : 2025-09-23 DOI:10.12659/AOT.949664

Göksel Guz, Rasim Onur Karaoğlu, Sezen Kumaş Solak, Ebru Burcu Demirgan, Serdar Demirgan

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引用次数: 0

Abstract

BACKGROUND Patients with chronic kidney disease (CKD) have a markedly increased cardiovascular risk, largely due to persistent endothelial dysfunction (ED). Kidney transplantation improves cardiovascular status, but whether transplant type-living donor (LDT) or cadaver donor transplantation (CDT)-differentially affects coronary endothelial function remains unclear. MATERIAL AND METHODS In this prospective observational study, 75 kidney transplant recipients (LDT: n=50; CDT: n=25) and 25 healthy controls (HC) underwent CFVR measurement at baseline (CFVR-1) and 6 months post-transplantation (CFVR-2). Left ventricular ejection fraction (LV-EF), diameters, and NT-proBNP were also assessed. Group comparisons and pre-/post-transplant changes were analyzed. RESULTS Baseline CFVR was higher in HC than in transplant groups (p0.05), but CFVR-1 0.05). A ≥10% EF increase occurred in 36% of patients in each group. CONCLUSIONS Kidney transplantation improves coronary endothelial function and cardiac performance regardless of donor type, though severe baseline CFVR impairment is more common in cadaveric recipients.

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肾移植类型对慢性肾病患者冠状动脉内皮功能的影响

背景：慢性肾脏疾病（CKD）患者心血管风险明显增加，主要是由于持续的内皮功能障碍（ED）。肾移植可改善心血管状况，但移植类型——活体供体（LDT）或尸体供体移植（CDT）对冠状动脉内皮功能的影响是否存在差异尚不清楚。材料和方法在这项前瞻性观察性研究中，75名肾移植受者（LDT: n=50; CDT: n=25）和25名健康对照（HC）在基线（CFVR-1）和移植后6个月（CFVR-2）进行了CFVR测量。左心室射血分数（LV-EF）、内径和NT-proBNP也被评估。分析各组比较和移植前后的变化。结果HC组CFVR基线高于移植组（p0.05）， CFVR-1基线高于移植组（p0.05）。两组中有36%的患者EF升高≥10%。结论：肾移植可改善冠状动脉内皮功能和心脏功能，与供体类型无关，但严重的基线CFVR损害在尸体受体中更为常见。

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来源期刊

Annals of Transplantation 医学-外科

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Annals of Transplantation is one of the fast-developing journals open to all scientists and fields of transplant medicine and related research. The journal is published quarterly and provides extensive coverage of the most important advances in transplantation. Using an electronic on-line submission and peer review tracking system, Annals of Transplantation is committed to rapid review and publication. The average time to first decision is around 3-4 weeks. Time to publication of accepted manuscripts continues to be shortened, with the Editorial team committed to a goal of 3 months from acceptance to publication. Expert reseachers and clinicians from around the world contribute original Articles, Review Papers, Case Reports and Special Reports in every pertinent specialty, providing a lot of arguments for discussion of exciting developments and controversies in the field.