Reflecting on barriers to continuous pharmaceutical crystallization

Giovanni Aprile, Cedric Devos, Thomas Vetter, Gerard Capellades, Kevin P. Girard, Christopher L. Burcham, Venkateswarlu Bhamidi, Daniel Green, Torsten Stelzer, Richard D. Braatz, Allan S. Myerson
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Abstract

This Comment explores why continuous crystallization, despite its success in other industries, remains underutilized in pharmaceutical manufacturing. Among other challenges, we highlight two core issues: the lack of off-the-shelf small-scale equipment with integrated monitoring tools, and the absence of compatible continuous downstream units for filtration and drying, both of which limit practical implementation.

Abstract Image

反思药物连续结晶的障碍
本评论探讨了为什么连续结晶尽管在其他行业取得了成功,但在制药制造中仍未得到充分利用。在其他挑战中,我们强调了两个核心问题:缺乏集成监测工具的现成小型设备,以及缺乏兼容的连续下游过滤和干燥装置,这两个问题都限制了实际实施。
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