Ana C. Andreazza, L. Felipe Barros, Alexander Behnke, Dorit Ben-Shachar, Sabina Berretta, Virginie-Anne Chouinard, Kim Do, Sharmili Edwin Thanarajah, Hannelore Ehrenreich, Peter Falkai, Judith Ford, Zachary Freyberg, Javier Gilbert-Jaramillo, Jill R. Glausier, Manu S. Goyal, Margaret Hahn, Suzana Herculano-Houzel, David Hofmann, Iris-Tatjana Kolassa, Matthias Mack, R. Nehir Mavioglu, Robert McCullumsmith, Yuri Milaneschi, Anthony J. A. Molina, Lilianne Mujica-Parodi, Dost Öngür, Martin Paulus, Daria Peleg-Raibstein, Ben Perry, Martin Picard, Toby Pillinger, Caroline Rae, Douglas Rothman, Zoltan Sarnyai, Johann Steiner, Rachel Upthegrove, Anthony C. Vernon, Melanie Wall, Corey Weistuch
{"title":"Brain and body energy metabolism and potential for treatment of psychiatric disorders","authors":"Ana C. Andreazza, L. Felipe Barros, Alexander Behnke, Dorit Ben-Shachar, Sabina Berretta, Virginie-Anne Chouinard, Kim Do, Sharmili Edwin Thanarajah, Hannelore Ehrenreich, Peter Falkai, Judith Ford, Zachary Freyberg, Javier Gilbert-Jaramillo, Jill R. Glausier, Manu S. Goyal, Margaret Hahn, Suzana Herculano-Houzel, David Hofmann, Iris-Tatjana Kolassa, Matthias Mack, R. Nehir Mavioglu, Robert McCullumsmith, Yuri Milaneschi, Anthony J. A. Molina, Lilianne Mujica-Parodi, Dost Öngür, Martin Paulus, Daria Peleg-Raibstein, Ben Perry, Martin Picard, Toby Pillinger, Caroline Rae, Douglas Rothman, Zoltan Sarnyai, Johann Steiner, Rachel Upthegrove, Anthony C. Vernon, Melanie Wall, Corey Weistuch","doi":"10.1038/s44220-025-00422-6","DOIUrl":null,"url":null,"abstract":"Brain function is critically dependent on energy metabolism. Research over the past half century has provided many insights into energy production and utilization in the brain, and identified ways that it can be improved in brain disorders. A parallel literature indicates that major aberrations exist in brain bioenergetics in neuropsychiatric disorders. Targeting bioenergetic abnormalities may be an efficacious approach to treatment for these conditions. In this Perspective, we provide a survey of the relevant literature on these topics and sketch the outlines of a research agenda to maximize the impact of future research and treatment interventions. This Perspective highlights the important role of energy metabolism in psychiatric disorders and sets the groundwork for future studies in the emerging field of metabolic psychiatry.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 7","pages":"763-771"},"PeriodicalIF":8.7000,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature mental health","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44220-025-00422-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Brain function is critically dependent on energy metabolism. Research over the past half century has provided many insights into energy production and utilization in the brain, and identified ways that it can be improved in brain disorders. A parallel literature indicates that major aberrations exist in brain bioenergetics in neuropsychiatric disorders. Targeting bioenergetic abnormalities may be an efficacious approach to treatment for these conditions. In this Perspective, we provide a survey of the relevant literature on these topics and sketch the outlines of a research agenda to maximize the impact of future research and treatment interventions. This Perspective highlights the important role of energy metabolism in psychiatric disorders and sets the groundwork for future studies in the emerging field of metabolic psychiatry.
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