Jessica L. Stelzel, Jonathan P. Schneck, Hai-Quan Mao, Joshua C. Doloff
{"title":"Oversimplified immunology is holding biomaterials back","authors":"Jessica L. Stelzel, Jonathan P. Schneck, Hai-Quan Mao, Joshua C. Doloff","doi":"10.1038/s44222-025-00320-7","DOIUrl":null,"url":null,"abstract":"Immune responses are complex, often defying rigid classifications. Instead of interpreting results according to reductionist categories, researchers should rely on comprehensive single-cell data to guide analysis and should remain open to unexpected immunological complexity.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 7","pages":"523-525"},"PeriodicalIF":37.6000,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature reviews bioengineering","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44222-025-00320-7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Immune responses are complex, often defying rigid classifications. Instead of interpreting results according to reductionist categories, researchers should rely on comprehensive single-cell data to guide analysis and should remain open to unexpected immunological complexity.